Evidence map›Paper›PMID 37828861›Full record

ArticleHuman vaccines & immunotherapeutics2023

SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccine.

Wan Muhammad Azfar Wan Shuaib, Izzatul Aliaa Badaruddin, Munirah Mansor, Sharifah Azura Salleh, Mohd Rohaizat Hassan, Steward Lindong, Shahril Nizam Samad, Hanita Othman

Open access · goldAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Wan Muhammad Azfar Wan ShuaibDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMC, Kuala Lumpur, Malaysia.ORCID 0000-0001-8542-0888
Izzatul Aliaa BadaruddinDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMC, Kuala Lumpur, Malaysia.ORCID 0000-0001-9825-1753
Munirah MansorDepartment of Laboratory Diagnostic Services (JPMD), Hospital Canselor Tuanku Muhriz, UKMMC, Kuala Lumpur, Malaysia.ORCID 0000-0002-6500-7823
Sharifah Azura SallehDepartment of Medical Microbiology & Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMC, Kuala Lumpur, Malaysia.ORCID 0000-0001-8645-0560
Mohd Rohaizat HassanDepartment of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMC, Kuala Lumpur, Malaysia.ORCID 0000-0002-4658-6532
Steward LindongDepartment of Laboratory Diagnostic Services (JPMD), Hospital Canselor Tuanku Muhriz, UKMMC, Kuala Lumpur, Malaysia.
Shahril Nizam SamadDepartment of Laboratory Diagnostic Services (JPMD), Hospital Canselor Tuanku Muhriz, UKMMC, Kuala Lumpur, Malaysia.
Hanita OthmanDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMC, Kuala Lumpur, Malaysia.ORCID 0000-0001-8971-9860
University Kebangsaan Malaysia Medical Centre · MYCM Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutralizing antibodies (NTAb) play a significant role in preventing and protecting against SARS-CoV-2 virus infection. Identifying NTAb is undoubtedly imperative in understanding the immunity toward COVID-19 better. However, it is interesting to note that the production of NTAb varies among individuals, especially among healthcare workers (HCWs), as they are exposed to the virus daily. Hence, we would like to investigate factors affecting the production of S-RBD IgG and NTAb among different categories of HCWs, particularly after receiving the third dose of the BNT162b2 mRNA COVID-19 Vaccine. A total of 361 HCWs from our hospital were prospectively enrolled and had their S-RBD IgG and NTAb titers measured. They were studied in relation to the degree of exposure to COVID-19, breakthrough infections, gender, age, race, household income, housing type, household number, and education levels. HCWs with the highest risk of exposure to COVID-19, breakthrough infections, and male gender displayed the highest median titers of both S-RBD IgG and NTAb, and the differences were statistically significant (

Indexed as

COVID-19SARS-CoV-2Antibodies, NeutralizingAntibodies, ViralBNT162 VaccineBreakthrough InfectionsCOVID-19 VaccinesHealth PersonnelHumansImmunoglobulin GMaleRNA, MessengerAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesImmunoglobulin GRNA, MessengerBNT162b2COVID-19healthcare workersneutralizing antibodiesSARS-CoV-2

Identifiers

PMID37828861
PMCPMC10578183
OpenAlexW4387600233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.