Evidence map›Paper›PMID 37828734›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi-Ethnic Study of Atherosclerosis (MESA).

Sally S Ong, Jeremy J Peavey, Kevin D Hiatt, Christopher T Whitlow, Rebecca M Sappington, Atalie C Thompson, Samuel N Lockhart, Haiying Chen, Suzanne Craft, Stephen R Rapp and 8 more

Open access · hybridAbstract read
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Sally S OngDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-3599-9021
Jeremy J PeaveyDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Kevin D HiattDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Christopher T WhitlowDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Rebecca M SappingtonDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Atalie C ThompsonDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Samuel N LockhartDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Haiying ChenDepartment of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Suzanne CraftDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Stephen R RappBiostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Annette L FitzpatrickDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Susan R HeckbertDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
José A LuchsingerDepartments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, New York, USA.
Barbara E K KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Stacy M MeuerDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Mary Frances CotchNational Eye Institute, National Institute of Health, Bethesda, Maryland, USA.
Tien Y WongSingapore Eye Research Institute, Singapore National Eye Center, Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.
Timothy M HughesDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Wake Forest University · USUniversity of Washington · USUniversity of Wisconsin–Madison · USColumbia University Irving Medical Center · USNational Eye Institute · USSingapore National Eye Center · SG

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAPP, STEPHEN R · 2016 to 2020
$12.2M
Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESAR01HL127659 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2015 to 2018
$7.4M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4M
The Macrovascular and Microvascular Contributions to Alzheimer's Disease: MESA VASCADR01AG054069 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M. · 2016 to 2020
$3.8M
Intramural NIH HHS ZIA EY000403NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1-TR-000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1-TR-001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1-TR-001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R01 HL127659NHLBI NIH HHS R01HL127659NIA NIH HHS K24 AG045334NIA NIH HHS P30 AG049638NIA NIH HHS P30AG049638NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG054069NIA NIH HHS R01AG054069NIA NIH HHS R01 AG058969NIA NIH HHS R01AG058969NIA NIH HHS R01 AG068629
6 · The paper itself

Abstract

introductionRetinal vascular network changes may reflect the integrity of the cerebral microcirculation, and may be associated with cognitive impairment.

methodsAssociations of retinal vascular measures with cognitive function and MRI biomarkers were examined amongst Multi-Ethnic Study of Atherosclerosis (MESA) participants in North Carolina who had gradable retinal photographs at Exams 2 (2002 to 2004, n = 313) and 5 (2010 to 2012, n = 306), and detailed cognitive testing and MRI at Exam 6 (2016 to 2018).

resultsAfter adjustment for covariates and multiple comparisons, greater arteriolar fractal dimension (FD) at Exam 2 was associated with less isotropic free water of gray matter regions (β = -0.0005, SE = 0.0024, p = 0.01) at Exam 6, while greater arteriolar FD at Exam 5 was associated with greater gray matter cortical volume (in mm

conclusionGreater arteriolar FD, reflecting greater complexity of the branching pattern of the retinal arteries, is associated with MRI biomarkers indicative of less neuroinflammation and neurodegeneration.

Indexed as

AtherosclerosisFractalsBiomarkersCognitionHumansNeuroimagingRetinal VesselsBiomarkersAlzheimer's diseasebranching anglecurvature tortuositydementiafractal dimensionMRI biomarkersretinal vascular network parameter

Identifiers

PMID37828734
PMCPMC10916935
OpenAlexW4387598669

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.