Evidence map›Paper›PMID 37828475›Full record

ArticleBMC musculoskeletal disorders2023

MRI-based volume measurement methods for staging primary lower extremity lymphedema: a single-center study of asymmetric volume difference-a diagnostic study.

Mengke Liu, Yan Zhang, Xingpeng Li, Qi Hao, Bin Li, Rengui Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mengke LiuDepartment of Radiology, Affiliated Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Yan ZhangDepartment of Radiology, Affiliated Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Xingpeng LiDepartment of Radiology, Affiliated Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Qi HaoDepartment of Radiology, Affiliated the ninth Clinical Medical College, Peking University, Beijing, 100038, China.
Bin LiDepartment of MRI, Affiliated Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. libin2434@bjsjth.cn.
Rengui WangDepartment of Radiology, Affiliated Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. wangrg@bjsjth.cn.
Capital Medical University · CNPeking University · CN

Funding

Beijing Municipal Administration of Hospitals Incubating Program PX2020030National Natural Science Foundation of China 61876216
6 · The paper itself

Abstract

backgroundLower extremity lymphedema (LEL) staging is mainly assessed by systems that solely depend on physical examinations and lack quantitative assessment based on modern imaging.

objectiveTo explore the value of MRI-based asymmetric volume measurements in the clinical staging of primary LEL.

methods92 patients with unilateral primary LEL underwent MRI examinations to determine the volume of the mid-calf (Vcl) calculated using the clinical dermatome method as well as the total volume (Vmri), musculoskeletal volume (VM), and subcutaneous volume (VS) volume of the middle calves. The difference between Vmri (DVmri) and VS (DVS) of the affected and unaffected calves was obtained and defined as the asymmetric volume difference. Meanwhile, the volume of the mid-calf (Vcl) and the difference in volume (DVcl) were calculated using the clinical circumferential method. The relationship between the asymmetric volume difference and clinical staging was then evaluated. Interobserver consistency was assessed through the intraclass correlation coefficient (ICC). Volume comparisons between the three groups were performed using the one-way analysis of variance (ANOVA) or the Kruskal-Wallis test. Spearman's correlation was used to assess volume and clinical stage correlation. The receiver operating characteristic (ROC) curve was used to evaluate the value of asymmetric volume difference for clinical staging.

resultsThe asymmetric volume difference was statistically significant in stage I compared to stages II and III (p < 0.05). The asymmetric volume difference (DVmri: r = 0.753; DVS: r = 0.759) correlated more with the clinical stage than the affected Vcl (r = 0.581), Vmri (r = 0.628), VS (r = 0.743), and DVcl (r = 0.718). The area under the ROC curve (AUC) for identifying the clinical stage by the asymmetric volume difference was greater than that for the affected Vcl, Vmri, VS, and DVcl, with DVS (AUC = 0.951) having the largest area under the curve to distinguish between stages I and II.

conclusionMRI-based asymmetric volume difference is an adjunctive measure for LEL clinical staging with good reproducibility. DVS could be the best indicator for differentiating between stages I and II of primary LEL.

Indexed as

LymphedemaHumansLegLower ExtremityMagnetic Resonance ImagingReproducibility of ResultsROC CurveLower extremityLymphedemaMagnetic resonance imaging

Identifiers

PMID37828475
PMCPMC10568749
OpenAlexW4387571800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.