Evidence map›Paper›PMID 37828468›Full record

ArticleBMC immunology2023

Methionine enkephalin(MENK) upregulated memory T cells in anti-influenza response.

Jing Tian, Wenrui Fu, Zifeng Xie, Xiaonan Wang, Miao Miao, Fengping Shan, Xiaodong Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jing TianDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, 121001, China.
Wenrui FuDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, 121001, China.
Zifeng XieDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, 121001, China.
Xiaonan WangBiostax Inc., 1317 Edgewater Dr., Ste 4882, Orlando, FL, 32804, USA.
Miao MiaoBiostax Inc., 1317 Edgewater Dr., Ste 4882, Orlando, FL, 32804, USA.
Fengping ShanDepartment of Immunology, School of Basic Medical Science, China Medical University, Shenyang, 110122, China. fpshan@cmu.edu.cn.
Xiaodong YuDepartment of Nursing, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China. 1036121766@qq.com.
Jinzhou Medical University · CNAffiliated Hospital of Jining Medical University · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel prophylactic drugs and vaccination strategies for protection against influenza virus should induce specific effector T-cell immune responses in pulmonary airways and peripheral lymphoid organs. Designing approaches that promote T-cell-mediated responses and memory T-cell differentiation would strengthen host resistance to respiratory infectious diseases. The results of this study showed that pulmonary delivery of MENK via intranasal administration reduced viral titres, upregulated opioid receptor MOR and DOR, increased the proportions of T-cell subsets including CD8

Indexed as

Influenza A virusInfluenza, HumanAnimalsCD8-Positive T-LymphocytesEnkephalin, MethionineHumansImmunologic MemoryMemory T CellsMiceMice, Inbred C57BLEnkephalin, MethionineAntiviral efficacyInfluenza A virusMemory T cellMethionine enkephalinOpioid receptor

Identifiers

PMID37828468
PMCPMC10571428
OpenAlexW4387580229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.