Evidence map›Paper›PMID 37828432›Full record

ArticleBMC nephrology2023

Ascending aortic aneurysm and histopathology in Alport syndrome: a case report.

Ali Kamiar, Qusai Alitter, Jose M C Capcha, Ali Saad, Keith A Webster, Lina A Shehadeh

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ali KamiarDepartment of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, Fl, United States.
Qusai AlitterInterdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States.
Jose M C CapchaDepartment of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, Fl, United States.
Ali SaadDepartments of Pathology and Pediatrics, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States.
Keith A WebsterIntegene International Holdings, LLC, Miami, FL, United States.
Lina A ShehadehDepartment of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, Fl, United States. lshehadeh@med.miami.edu.
University of Miami · USBaylor College of Medicine · US

Funding

The Role of Osteopontin-OGDHL Axis in HFPEFR01HL140468 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHEHADEH, LINA A · 2018 to 2022
$1.8M
NHLBI NIH HHS R01 HL140468
6 · The paper itself

Abstract

backgroundAlport syndrome (AS) is caused by mutations in type IV collagen genes that typically target and compromise the integrity of basement membranes in kidney, ocular, and sensorineural cochlear tissues. Type IV and V collagens are also integral components of arterial walls, and whereas collagenopathies including AS are implicated in aortic disease, the incidence of aortic aneurysm in AS is unknown probably because of underreporting. Consequently, AS is not presently considered an independent risk factor for aortic aneurysm and more detailed case studies including histological evidence of basement membrane abnormalities are needed to determine such a possible linkage. CASE PRESENTATION: Here, we present unique histopathological findings of an ascending aortic aneurysm collected at the time of surgery from an AS patient wherein hypertension was the only other known risk factor.

conclusionsThe studies reveal classical histological features of aortic aneurysm, including atheroma, lymphocytic infiltration, elastin disruption, and myxoid degeneration with probable AS association.

Indexed as

Aneurysm, Ascending AortaAortic AneurysmNephritis, HereditaryCollagen Type IVHumansKidneyCollagen Type IVAlport syndromeAneurysm repairAscending aortic aneurysmAscending aortic histopathologyHypertensionKidney dysfunction

Identifiers

PMID37828432
PMCPMC10568822
OpenAlexW4387571790

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.