Evidence map›Paper›PMID 37828424›Full record

ArticleBMC genomics2023

Starvation induces hepatopancreas atrophy in Chinese mitten crab (Eriocheir sinensis) by inhibiting angiogenesis.

Hongli Liu, Yang Feng, Ma Yang, Ya Huang, Minghao Li, Yi Geng, Ping Ouyang, Defang Chen, Shiyong Yang, Lizi Yin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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  5. Temporal and Spatial Signatures ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hongli Liu *Department of Aquaculture, College of Animal Science & Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Yang Feng *Department of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chendu, Sichuan, 611130, China.
Ma Yang *Fisheries Research Institute, Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan, 611130, China.
Ya HuangDepartment of Aquaculture, College of Animal Science & Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Minghao LiDepartment of Aquaculture, College of Animal Science & Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Yi GengDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chendu, Sichuan, 611130, China.
Ping OuyangDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chendu, Sichuan, 611130, China.
Defang ChenDepartment of Aquaculture, College of Animal Science & Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Shiyong YangDepartment of Aquaculture, College of Animal Science & Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Lizi YinDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chendu, Sichuan, 611130, China.
Liangyu LiFisheries Research Institute, Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan, 611130, China. liliangyu507@163.com.
Xiaoli HuangDepartment of Aquaculture, College of Animal Science & Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. hxlscau@126.com.
Sichuan Agricultural University · CNChengdu Academy of Agriculture and Forestry Sciences · CN

Funding

Chengdu Science and Technology Project 2022-YF05-00636-SNSichuan Science and Technology Program 2021JDRCO125
6 · The paper itself

Abstract

backgroundThe hepatopancreas of crustaceans serves as a significant organ for both the synthesis and secretion of digestive enzymes, as well as energy storage. In the event of food shortage, the hepatopancreas can provide energy for survival. To investigate the potential regulatory mechanisms of the hepatopancreas in response to starvation in Eriocheir Sinensis, transcriptome analysis, histological study and qRT-PCR were performed.

resultsThe results showed that starvation caused a decrease in the hepatopancreas index of E. sinensis, which had certain effects on the tissue structure, metabolism and angiogenesis in the hepatopancreas. In addition, WGCNA and linear regression analysis showed that the genes significantly related to the hepatopancreas index were mainly enriched in the angiogenesis pathway, in which AKT signaling played an important role. Starvation may inhibit AKT signaling pathway by reducing the expression of TGFBI, HSP27, HHEX, and EsPVF1, thereby hindering angiogenesis, promoting apoptosis, and leading to hepatopancreas atrophy.

conclusionThese results indicate that AKT plays an important role in the angiogenesis pathway and apoptosis of the starvation induced hepatopancreas index reduction, which is beneficial to further understand the effect of starvation stress on hepatopancreas of Chinese mitten crab.

Indexed as

BrachyuraHepatopancreasAnimalsGene Expression ProfilingProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-aktAngiogenesisEriocheir sinensisHepatopancreasStarvation

Identifiers

PMID37828424
PMCPMC10571328
OpenAlexW4387569428

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.