Evidence map›Paper›PMID 37828399›Full record

ArticleNature chemical biology2023

Widespread biosynthesis of 16-carbon terpenoids in bacteria.

Yao-Tao Duan, Aikaterini Koutsaviti, Maria Harizani, Codruta Ignea, Vassilios Roussis, Yong Zhao, Efstathia Ioannou, Sotirios C Kampranis

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 38 citations in OpenAlex.

  1. Biosynthesis of the Fully Saturated CAngewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Antifungal mechanism against Candida albicans and antitumor activity of phenazines produced by Pseudomonas sp. strain DH.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  4. Article
  5. Structural Revision of the CAngewandte Chemie (International ed. in English) · 2026
    Article
  6. Homoterpene Biosynthesis in Fungi.Angewandte Chemie (International ed. in English) · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. The microbial biosynthesis of noncanonical terpenoids.Applied microbiology and biotechnology · 2024
    Review
  13. Review
  14. Article
  15. Inhibitory effect ofFrontiers in microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Yao-Tao DuanBiochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C, Denmark.ORCID 0000-0002-7534-7813
Aikaterini KoutsavitiSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens, Greece.
Maria HarizaniSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens, Greece.
Codruta IgneaBiochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C, Denmark.ORCID 0000-0002-6304-9413
Vassilios RoussisSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens, Greece.
Yong ZhaoBiochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C, Denmark. yong.zhao@plen.ku.dk.ORCID 0000-0002-0423-5232
Efstathia IoannouSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens, Greece. eioannou@pharm.uoa.gr.ORCID 0000-0003-3103-4951
Sotirios C KampranisBiochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C, Denmark. soka@plen.ku.dk.ORCID 0000-0001-6208-1684
National and Kapodistrian University of Athens · GRUniversity of Copenhagen · DK

Funding

China Scholarship Council (CSC) 201904910446Ministry of Education and Religious Affairs, Sport and Culture (Greece Ministry of Education and Religious Affairs, Sport and Culture) 70/3/14685Novo Nordisk Fonden (Novo Nordisk Foundation) NNF19OC0055204Novo Nordisk Fonden (Novo Nordisk Foundation) NNF22OC0080100
6 · The paper itself

Abstract

Terpenoids are the most diverse group of specialized metabolites with numerous applications. Their biosynthesis is based on the five-carbon isoprene building block and, as a result, almost all terpenoids isolated to date are based on backbones that contain multiples of five carbon atoms. Intrigued by the discovery of an unusual bacterial terpenoid with a 16-carbon skeleton, here we investigate whether the biosynthesis of 16-carbon terpenoids is more widespread than this single example. We mine bacterial genomic information and identify potential C

Indexed as

BacteriaTerpenesSaccharomyces cerevisiaeSynthetic BiologyTerpenes

Identifiers

PMID37828399
OpenAlexW4387580993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.