ArticleTranslational psychiatry2023
Music prevents stress-induced depression and anxiety-like behavior in mice.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The safety and effectiveness of music medicine as an intervention for depression: A systematic evaluation and re-evaluation.Brain and behavior · 2024Pooled it
- Compound Ciwujia Granules Attenuate Stress-Induced Anxiety- and Depression-Like Behaviors via Inhibition of TNF-α-Associated Neuroinflammation in the dmPFC.CNS neuroscience & therapeutics · 2026Article
- Dihydromyricetin attenuates chronic stress-induced depressive-like phenotypes and modulates Akt/FoxO3a-related signaling in the hippocampus.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Structured Light Music for Stress Adaptation: The BDNF/TrkB Signaling Axis Mediating Neuroplasticity and HPA Axis Regulation.Brain sciences · 2026Review
- Effects of Classical Music on Behavioral and Physiological Stress Markers in Socially Isolated Prairie Voles.Annals of the New York Academy of Sciences · 2026Article
- Music and Exercise in Concert: Uncovering Synergistic Mechanisms for Enhancing Brain Health and Cognitive Resilience-A Narrative Review.Brain and behavior · 2026Review
- Metabolomics and Proteomics Analyses Reveal the Protective Effect of Crocetin Against Depressive-Like Behaviors Mice.Neurochemical research · 2026Article
- Suanzao Ren Decoction Alleviates Anxiety-Like Behavior and Cognitive Dysfunction in Chronic Unpredictable Stress Rats by Modulating Oxidative Stress and Autophagy.Brain and behavior · 2026Article
- Neuronal Igfbp2 deficiency in the prefrontal cortex impairs cognition through synaptic dysfunction in male mice.iScience · 2026Article
- Article
- Unraveling sexually dimorphic offspring behaviors: maternal premating stress and the neuro-microbial-metabolic network.Molecular psychiatry · 2026Article
- Physical exercise mitigates chronic psychological stress-induced vascular inflammation via the BDNF-Kif4-TARM1 axis.Clinical and translational medicine · 2026Article
- Cerebral organoid exosomes reversed behavioral deficits by repressing NLRP3-mediated neuroinflammation in stress models.iScience · 2026Article
- Long-term social isolation during adolescence exacerbated cardiac dysfunction after myocardial infarction.Translational psychiatry · 2026Article
- Cognitive and Motor Dysfunction in STXBP1 R406H Mice.Journal of molecular neuroscience : MN · 2026Article
- A primary auditory cortex-anterior cingulate cortex circuit underlying cross-modal visceral pain modulation.Nature communications · 2026Article
- α2δ-1-NMDAR1 complex in the hypothalamic paraventricular nucleus mediates anxiety-induced sympathetic hyperactivity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Electroacupuncture to point Baihui confers anxiolytic effects by promoting oxytocin release from PVN in Mice.Chinese medicine · 2026Article
- Effects of Music Intervention on Pain, Mood, Sleep, and Heart Rate Variability in Patients with Chronic Pain: A Randomized Controlled Trial.Journal of pain research · 2026Article
- Measurement of Serum Parameters Attributes the Therapeutic Effects of Music Therapy to Augmented Stress-Coping Ability and Diminished Systemic Inflammation.Depression and anxiety · 2026Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Depression is the most prevalent psychiatric disorder worldwide and remains incurable; however, there is little research on its prevention. The leading cause of depression is stress, and music has been hypothesized to alleviate stress. To examine the potential beneficial effects of music on stress and depression, we subjected mice to chronic unpredictable mild stress (CUMS) during the day and music at night. Strikingly, our results indicated that music completely prevented CUMS-induced depression and anxiety-like behaviors in mice, as assessed by the open field, tail suspension, sucrose preference, novelty suppressed feeding, and elevated plus maze tests. We found that listening to music restored serum corticosterone levels in CUMS mice, which may contribute to the beneficial effects of music on the mouse brain, including the restoration of BDNF and Bcl-2 levels. Furthermore, listening to music prevented CUMS-induced oxidative stress in the serum, prefrontal cortex, and hippocampus of mice. Moreover, the CUMS-induced inflammatory responses in the prefrontal cortex and hippocampus of mice were prevented by listening to music. Taken together, we have demonstrated for the first time in mice experiments that listening to music prevents stress-induced depression and anxiety-like behaviors in mice. Music may restore hypothalamus-pituitary-adrenal axis homeostasis, preventing oxidative stress, inflammation, and neurotrophic factor deficits, which had led to the observed phenotypes in CUMS mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.