Evidence map›Paper›PMID 37827967›Full record

ArticleVaccine2023

Antibodies elicited by Plasmodium falciparum circumsporozoite proteins lacking sequentially deleted C-terminal amino acids reveal mouse strain and epitopes specific differences.

Clifford T H Hayashi, Yi Cao, Fidel Zavala, Hayk Simonyan, Colin N Young, Nirbhay Kumar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Clifford T H HayashiDepartment of Global Health, Milken Institute School of Public Health, George Washington University, Washington DC 20052, USA.
Yi CaoDepartment of Global Health, Milken Institute School of Public Health, George Washington University, Washington DC 20052, USA.
Fidel ZavalaJohns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21215, USA.
Hayk SimonyanDepartment of Pharmacology and Physiology, School of Medicine and Health Sciences, George Washington University, Washington DC 20052, USA.
Colin N YoungDepartment of Pharmacology and Physiology, School of Medicine and Health Sciences, George Washington University, Washington DC 20052, USA.
Nirbhay KumarDepartment of Global Health, Milken Institute School of Public Health, George Washington University, Washington DC 20052, USA. Electronic address: nkumar@gwu.edu.
Milken Institute · USGeorge Washington University · USJohns Hopkins University · US

Funding

Combination Vaccines to Interrupt Malaria TransmissionR01AI127544 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KUMAR, NIRBHAY · 2017 to 2020
$2.2M
NIAID NIH HHS R01 AI127544
6 · The paper itself

Abstract

Malaria affects ∼ ¼ billion people globally and requires the development of additional tools to aid in elimination efforts. The recently approved RTS,S/AS01 vaccine represents a positive step, however, the moderate efficacy necessitates the development of more efficacious vaccines. PfCSP is a key target antigen for pre-erythrocytic vaccines aimed at preventing Plasmodium falciparum malaria infections. Epitopes within the central repeat region and at the junction of the repeat and N-terminal domain are well documented as major protective B cell epitopes. On the other hand, a majority of antibodies against the epitopes in the C-terminal domain, have been shown to be non-protective against sporozoite challenge. The C-terminal domain, however, contains CD4

Indexed as

Antibodies, ProtozoanEpitopes, T-LymphocyteMalaria, FalciparumMalaria VaccinesMice, Inbred BALB CPlasmodium falciparumProtozoan ProteinsVaccines, DNAAnimalsEpitopesEpitopes, B-LymphocyteFemaleMiceSporozoitesAntibodies, Protozoancircumsporozoite protein, ProtozoanEpitopesEpitopes, B-LymphocyteEpitopes, T-LymphocyteMalaria VaccinesProtozoan ProteinsVaccines, DNACircumsporozoite proteinMalariaPlasmodium falciparumVaccine

Identifiers

PMID37827967
PMCPMC11004087
OpenAlexW4387475730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.