Evidence map›Paper›PMID 37827846›Full record

ArticleNeurology2023

Pearls & Oy-sters: Leber Hereditary Optic Neuropathy-Plus Masquerading as Neuromyelitis Optica Spectrum Disorder in a 2-Year-Old Child.

Alex Sunshine, Quinton J Mandle, Ana M Cabal Herrera, Bianca Zapanta, Hersh Varma, Setty Magaña

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alex SunshineFrom the Neurology (A.S., Q.J.M., S.M.); Pediatrics (A.M.C.H.); Genetics (B.Z.); and Ophthalmology (H.V.), Nationwide Children's Hospital.ORCID 0000-0002-7298-9474
Quinton J MandleFrom the Neurology (A.S., Q.J.M., S.M.); Pediatrics (A.M.C.H.); Genetics (B.Z.); and Ophthalmology (H.V.), Nationwide Children's Hospital.ORCID 0000-0002-1913-4653
Ana M Cabal HerreraFrom the Neurology (A.S., Q.J.M., S.M.); Pediatrics (A.M.C.H.); Genetics (B.Z.); and Ophthalmology (H.V.), Nationwide Children's Hospital.
Bianca ZapantaFrom the Neurology (A.S., Q.J.M., S.M.); Pediatrics (A.M.C.H.); Genetics (B.Z.); and Ophthalmology (H.V.), Nationwide Children's Hospital.ORCID 0009-0001-9180-1107
Hersh VarmaFrom the Neurology (A.S., Q.J.M., S.M.); Pediatrics (A.M.C.H.); Genetics (B.Z.); and Ophthalmology (H.V.), Nationwide Children's Hospital.ORCID 0009-0009-8019-2041
Setty MagañaFrom the Neurology (A.S., Q.J.M., S.M.); Pediatrics (A.M.C.H.); Genetics (B.Z.); and Ophthalmology (H.V.), Nationwide Children's Hospital.ORCID 0000-0002-2450-3206

Funding

Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2M
NINDS NIH HHS K12 NS098482
6 · The paper itself

Abstract

"Leber hereditary optic neuropathy (LHON-Plus)" is a phenotype of LHON that is characterized by extraocular neurologic manifestations, which may be the first manifestations of the disease.

Indexed as

Neuromyelitis OpticaOptic Atrophy, Hereditary, LeberChild, PreschoolHumans

Identifiers

PMID37827846
PMCPMC10791055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.