Evidence map›Paper›PMID 37827807›Full record

ArticleBMJ open respiratory research2023

Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis - Pneumonia Metabolism in Ageing (PUMA).

Frances S Grudzinska, Aduragbemi A Faniyi, Aaron Scott, Elizabeth Sapey, David R Thickett

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Frances S GrudzinskaBirmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK F.Grudzinska@bham.ac.uk.ORCID 0000-0002-0952-0163
Aduragbemi A FaniyiBirmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
Aaron ScottBirmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
Elizabeth SapeyBirmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.ORCID 0000-0003-3454-5482
David R ThickettBirmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
University of Birmingham · GB

Funding

Department of Health NIHR129593Department of Health NIHR131600Medical Research Council MR/S002782/1
6 · The paper itself

Abstract

introductionCommunity-acquired pneumonia has high mortality and is associated with significant healthcare costs. In older adults with community-acquired pneumonia neutrophil dysfunction has been identified and is associated with poor outcomes for patients. Immunometabolism is a rapidly developing field which links immune cell function to metabolism. This study aims to explore neutrophil metabolism in community-acquired pneumonia. METHODS AND ANALYSIS: Pneumonia Metabolism in Ageing study is a prospective observational study recruiting older adults hospitalised with community-acquired pneumonia to examine neutrophil function and metabolic status. Controls will be older adults with no acute illness. The primary endpoint is neutrophil chemotaxis. ETHICS AND DISSEMINATION: The study has ethical approval from the Research Ethics Committee Wales, reference 19/WA/0299. This study involves participants who may lack the capacity to consent to research involvement, in this situation, personal or professional assent will be sought. The results from this study will be submitted for publication in peer-reviewed journals and disseminated at local and international conferences.

Indexed as

Community-Acquired InfectionsPneumoniaSepsisAgedAgingApoptosis Regulatory ProteinsCohort StudiesHumansNeutrophilsObservational Studies as TopicApoptosis Regulatory ProteinsBacterial InfectionInnate ImmunityNeutrophil BiologyPneumoniaRespiratory Infection

Identifiers

PMID37827807
PMCPMC10582892
OpenAlexW4387581128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.