Evidence map›Paper›PMID 37827519›Full record

ArticleMacromolecular bioscience2024

A Novel PEtOx-Based Nanogel Targeting Prostate Cancer Cells for Drug Delivery.

Sevgi Gülyüz, Melike Sessevmez, Gokcen Ukuser, Melek Parlak Khalily, Selen Tiryaki, Tarik Sipahioglu, Kaan Birgül, İpek Ömeroğlu, Salih Özçubukçu, Dilek Telci and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Sevgi GülyüzMaterial Technologies, Marmara Research Center, TUBITAK, Gebze, Kocaeli, 41470, Turkey.ORCID https://orcid.org/0000-0002-2576-3085
Melike SessevmezDepartment of Pharmaceutical Technology, Istanbul University, Istanbul, 34116, Turkey.ORCID https://orcid.org/0000-0002-6233-9574
Gokcen UkuserMaterial Technologies, Marmara Research Center, TUBITAK, Gebze, Kocaeli, 41470, Turkey.ORCID https://orcid.org/0000-0003-1896-8987
Melek Parlak KhalilyDepartment of Basic Science and Health, Cannabis Research Institute, Yozgat Bozok University, Yozgat, 66100, Turkey.ORCID https://orcid.org/0000-0002-5402-0467
Selen TiryakiDepartment of Genetics and Bioengineering, Yeditepe University, Istanbul, 34755, Turkey.ORCID https://orcid.org/0000-0002-2940-7678
Tarik SipahiogluDepartment of Genetics and Bioengineering, Yeditepe University, Istanbul, 34755, Turkey.ORCID https://orcid.org/0000-0003-2250-2143
Kaan BirgülDepartment of Pharmaceutical Chemistry, School of Pharmacy, Bahçeşehir University, Beşiktaş, Istanbul, 34353, Turkey.ORCID https://orcid.org/0000-0003-3963-4687
İpek ÖmeroğluDepartment of Chemistry, Gebze Technical University, Gebze, Kocaeli, 41400, Turkey.
Salih ÖzçubukçuDepartment of Chemistry, Middle East Technical University, Ankara, 06800, Turkey.ORCID https://orcid.org/0000-0001-5981-1391
Dilek TelciDepartment of Genetics and Bioengineering, Yeditepe University, Istanbul, 34755, Turkey.ORCID https://orcid.org/0000-0002-2793-6533
Ş Güniz KüçükgüzelDepartment of Pharmaceutical Chemistry, Fenerbahçe University, Ataşehir, Istanbul, 34758, Turkey.ORCID https://orcid.org/0000-0001-9405-8905
Mahmut DurmuşDepartment of Chemistry, Gebze Technical University, Gebze, Kocaeli, 41400, Turkey.ORCID https://orcid.org/0000-0003-0440-7345
Erdal CevherDepartment of Pharmaceutical Technology, Istanbul University, Istanbul, 34116, Turkey.ORCID https://orcid.org/0000-0002-0486-2252
Özgür YılmazMaterial Technologies, Marmara Research Center, TUBITAK, Gebze, Kocaeli, 41470, Turkey.ORCID https://orcid.org/0000-0003-3892-2775
Scientific and Technological Research Council of Turkey · TRYeditepe University · TRGebze Technical University · TRIstanbul Technical University · TRBahçeşehir University · TRFenerbahçe University · TRMiddle East Technical University · TRYozgat Bozok Üniversitesi · TR

Funding

Turkish Scientific and Technological CouncilTurkish Scientific and Technological Council TUBITAK-215S009Turkish Scientific and Technological Council TUBITAK-315S049
6 · The paper itself

Abstract

This study focuses on creating a specialized nanogel for targeted drug delivery in cancer treatment, specifically targeting prostate cancer. This nanogel (referred to as SGK 636/Peptide 563/PEtOx nanogel) is created using hydrophilic poly(2-ethyl-2-oxazoline) (PEtOx) through a combination of living/cationic ring-opening polymerization (CROP) and alkyne-azide cycloaddition (CuAAC) "click" chemical reactions. A fluorescent probe (BODIPY) is also conjugated with the nanogel to monitor drug delivery. The characterizations through

Indexed as

Drug Delivery SystemsPolyethyleneimineProstatic NeoplasmsDrug CarriersHumansMaleNanogelsPeptidesPolyethylene GlycolsSpectroscopy, Fourier Transform InfraredDrug CarriersNanogelsPeptidespolyethylene glycol polyethyleneimine nanogelPolyethylene GlycolsPolyethyleneimineCuAAC click chemistrycytotoxicitynanogelspeptideprostate cancerstar poly(2-ethyl-2-oxazoline)targeted drug delivery

Identifiers

PMID37827519
PMCPMC13420752
OpenAlexW4387566828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.