Evidence map›Paper›PMID 37827483›Full record

ReviewFertility and sterility2023

Endocrine-disrupting chemicals and male reproductive health.

Lidia Mínguez-Alarcón, Audrey J Gaskins, John D Meeker, Joseph M Braun, Jorge E Chavarro

Open access · bronzeAbstract readReview
In one paragraph

Review in Fertility and sterility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Review
  6. Endocrine Disruption and Male Fertility.Current environmental health reports · 2026
    Review
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  9. Long-Term Epidemiological Trends and Regional Disparities in Male Infertility in Central Asia (1991-2023).International journal of environmental research and public health · 2026
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Lidia Mínguez-AlarcónChanning Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Audrey J GaskinsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, Rhode Island.
Jorge E ChavarroChanning Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address: jchavarr@hsph.harvard.edu.
Brigham and Women's Hospital · USBrown University · USEmory University · USUniversity of Michigan · US

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
PCBs, Phthalates and Male Reproductive HealthR01ES009718 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HAUSER, RUSS B · 1999 to 2018
$11.6M
Exposure to phthalates and OP flame retardants and long-term maternal cardiovascular and metabolic healthR01ES033651 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENDA M BIRMANN, Lidia Minguez Alarcon · 2022 to 2026
$3.3M
Maternal and Paternal Preconception Environmental Exposures and Children's HealthR01ES027408 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BRAUN, JOSEPH M, HAUSER, RUSS B · 2018 to 2022
$3.0M
Maternal and Paternal Flame Retardant Exposure, Impact on Fertility and PregnancyR01ES022955 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HAUSER, RUSS B, MEEKER, JOHN D. · 2014 to 2018
$2.9M
Male pesticide exposure, reproductive health and epigeneticsR01ES034700 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Lidia Minguez Alarcon · 2023 to 2026
$2.7M
NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES009718NIEHS NIH HHS R01 ES022955NIEHS NIH HHS R01 ES027408NIEHS NIH HHS R01 ES033651NIEHS NIH HHS R01 ES034700
6 · The paper itself

Abstract

Modifiable factors, such as environmental exposures, can impact human fertility. The objective of this review is to summarize the potential effects of exposure to important endocrine-disrupting chemicals on male reproductive health. Most experimental and animal data demonstrate strong evidence for the negative effects of exposure to phenols, phthalates, pesticides, and perfluoroalkyl and polyfluoroalkyl substances on male reproductive health. Although evidence of negative associations in humans was overall strong for phthalates and pesticides, limited and inconclusive relationships were found for the other examined chemical biomarkers. Reasons for the discrepancies in results include but are not limited to, differences in study populations, exposure concentrations, number of samples collected, sample sizes, study design, and residual confounding. Additional studies are needed, particularly for newer phenols and perfluoroalkyl and polyfluoroalkyl substances, given the scarce literature on the topic and increasing exposures over time.

Indexed as

Endocrine DisruptorsEnvironmental PollutantsFluorocarbonsPesticidesAnimalsEnvironmental ExposureHumansMalePhenolsReproductive HealthEndocrine DisruptorsEnvironmental PollutantsFluorocarbonsPesticidesPhenolsendocrine disruptorsmale fertilityspermatogenesistesticular function

Identifiers

PMID37827483
PMCPMC10841502
OpenAlexW4387537439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.