Evidence map›Paper›PMID 37827238›Full record

ArticleAnaerobe2023

Impact of nicotine and cotinine on macrophage inflammatory plasticity via vesicular modifications in gastrointestinal bacteria.

Jourdan E Lakes, Xu Fu, Brock T Harvey, Khaga R Neupane, Surya P Aryal, Jessica L Ferrell, Michael D Flythe, Christopher I Richards

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anaerobe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jourdan E LakesDepartment of Chemistry, College of Arts & Sciences, University of Kentucky, Lexington, KY, USA. Electronic address: jela237@uky.edu.
Xu FuDepartment of Chemistry, College of Arts & Sciences, University of Kentucky, Lexington, KY, USA. Electronic address: xufu@uky.edu.
Brock T HarveyDepartment of Chemistry, College of Arts & Sciences, University of Kentucky, Lexington, KY, USA. Electronic address: brock_harvey@uky.edu.
Khaga R NeupaneDepartment of Chemistry, College of Arts & Sciences, University of Kentucky, Lexington, KY, USA. Electronic address: krne226@uky.edu.
Surya P AryalDepartment of Chemistry, College of Arts & Sciences, University of Kentucky, Lexington, KY, USA. Electronic address: Aryalsurya@uky.edu.
Jessica L FerrellUSDA Agricultural Research Service Forage-Animal Production Research Unit, Lexington, KY, USA. Electronic address: jessica.ferrell@usda.gov.
Michael D FlytheUSDA Agricultural Research Service Forage-Animal Production Research Unit, Lexington, KY, USA; Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA. Electronic address: michael.flythe@usda.gov.
Christopher I RichardsDepartment of Chemistry, College of Arts & Sciences, University of Kentucky, Lexington, KY, USA. Electronic address: chris.richards@uky.edu.
University of Kentucky · USAgricultural Research Service · US

Funding

Training in Drug Abuse Related Research.T32DA016176 · NIDA · UNIVERSITY OF KENTUCKY · PI DWOSKIN, LINDA P · 2004 to 2020
$4.0M
Ex vivo single molecule tools to analyze membrane receptor dynamicsR01GM138837 · NIGMS · UNIVERSITY OF KENTUCKY · PI RICHARDS, CHRISTOPHER I · 2021 to 2024
$1.2M
NIDA NIH HHS T32 DA016176NIGMS NIH HHS R01 GM138837
6 · The paper itself

Abstract

objectivesThis study aimed to elucidate mechanistic explanation(s) for compositional changes to enteric microbiota by determining the impacts of continuous nicotine/cotinine exposure on representative gastrointestinal bacteria and how these alterations impact innate immune cell plasticity.

methodsIn vitro cultures of the gastrointestinal bacteria (Bacteroides fragilis 25285, Prevotella bryantii B

resultsNicotine/cotinine exposure differentially affected metabolism of all bacteria tested in a Gram (nicotine) and concentration-dependent (cotinine) manner. Physiological studies demonstrated changes in vesiculation number and protein cargo following nicotine/cotinine exposures. Continuous exposure to 1 μM nicotine and 10 μM cotinine concentrations reduced total protein cargo of Gram (-) - 25285 and B

conclusionsNicotine/cotinine exposure differentially alters bacterial metabolism and vesicle physiology, ultimately impacting the inflammatory response of tolerogenic macrophages.

Indexed as

CotinineNicotineBacteriaMacrophagesCotinineNicotineCytokine responseMetabolismMicrobiotaNicotineSubstance use disorderVesiculation

Identifiers

PMID37827238
PMCPMC10841519
OpenAlexW4387492341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.