Evidence map›Paper›PMID 37827196›Full record

ArticleACS applied materials & interfaces2023

In Situ Photo-crosslinkable Hyaluronic Acid/Gelatin Hydrogel for Local Nitric Oxide Delivery.

Daniele M Catori, Laura C E da Silva, Matheus F de Oliveira, Grace H Nguyen, Joseph C Moses, Elizabeth J Brisbois, Hitesh Handa, Marcelo G de Oliveira

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Nitric Oxide-ReleasingPharmaceutics · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Daniele M CatoriInstitute of Chemistry, University of Campinas, UNICAMP, Campinas 13083-970, São Paulo, Brazil.
Laura C E da SilvaInstitute of Chemistry, University of Campinas, UNICAMP, Campinas 13083-970, São Paulo, Brazil.ORCID 0000-0002-9191-3440
Matheus F de OliveiraInstitute of Chemistry, University of Campinas, UNICAMP, Campinas 13083-970, São Paulo, Brazil.
Grace H NguyenSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens 30602, Georgia, United States.
Joseph C MosesSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens 30602, Georgia, United States.ORCID 0000-0001-9794-8196
Elizabeth J BrisboisSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens 30602, Georgia, United States.ORCID 0000-0002-9283-5448
Hitesh HandaSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens 30602, Georgia, United States.ORCID 0000-0002-9369-7374
Marcelo G de OliveiraInstitute of Chemistry, University of Campinas, UNICAMP, Campinas 13083-970, São Paulo, Brazil.ORCID 0000-0002-9371-9975
Universidade Estadual de Campinas (UNICAMP) · BRUniversity of Georgia · US

Funding

Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applicationsR01HL134899 · NHLBI · UNIVERSITY OF GEORGIA · PI HANDA, HITESH · 2017 to 2025
$3.0M
Bioinspired antifouling and thromboresistant polymers for blood-contacting interfacesR01HL151473 · NHLBI · UNIVERSITY OF GEORGIA · PI BRISBOIS, ELIZABETH JOY · 2020 to 2023
$1.4M
NHLBI NIH HHS R01 HL134899NHLBI NIH HHS R01 HL151473
6 · The paper itself

Abstract

An increasing number of studies have shown that the local release of nitric oxide (NO) from hydrogels stimulates tissue regeneration by modulating cell proliferation, angiogenesis, and inflammation. The potential biomedical uses of NO-releasing hydrogels can be expanded by enabling their application in a fluid state, followed by controlled gelation triggered by an external factor. In this study, we engineered a hydrogel composed of methacrylated hyaluronic acid (HAGMA) and thiolated gelatin (GELSH) with the capacity for in situ photo-cross-linking, coupled with localized NO release. To ensure a gradual and sustained NO release, we charged the hydrogels with poly(l-lactic-

Indexed as

GelatinHyaluronic AcidHydrogelsNitric OxideSulfhydryl CompoundsGelatinHyaluronic AcidHydrogelsNitric OxideSulfhydryl Compoundsgelatinhyaluronic acidhydrogelsin situ cross-linkingnitric oxidetissue regeneration

Identifiers

PMID37827196
PMCPMC11537030
OpenAlexW4387566866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.