Evidence map›Paper›PMID 37827115›Full record

ReviewCell host & microbe2023

Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology.

Lindsey Dzierozynski, Jessica Queen, Cynthia L Sears

Abstract readReview
In one paragraph

Review in Cell host & microbe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Emerging advances in intestinal models for in vitro preclinical research.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  4. Review
  5. Efficacy and Safety ofFood science & nutrition · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lindsey DzierozynskiDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Baltimore, MD, USA.
Jessica QueenDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cynthia L SearsDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Bloomberg∼Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: csears@jhmi.edu.

Funding

Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI JAFFEE, ELIZABETH M. · 1993 to 2022
$54.6M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
Pathogenesis of Early Onset Colorectal Cancer: Microbiome Contributions and MechanismsR01CA264217 · NCI · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 2021 to 2025
$2.3M
NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA264217NCI NIH HHS T32 CA009110
6 · The paper itself

Abstract

Although environmental impacts on the host microbiome have been well studied, it is less certain whether and how host genetics impact the microbiome. This commentary discusses current literature supporting host genetic influences on resident species and pathogenic microbes. Mechanistic experimental studies are warranted to understand host gene-microbiome interplay.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaBiologycancercoloncolorectal cancerguthost genesinflammatory bowel diseaseinter-kingdom interactionsmicrobial evolutionmicrobiotamutualism

Identifiers

PMID37827115
PMCPMC11272393

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.