ArticleJournal of clinical pathology1986
Colorectal goblet cell sialomucin heterogeneity: its relation to malignant disease.
Article in Journal of clinical pathology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- NXPE1 alters the sialoglycome by acetylating sialic acids in the human colon.Nature communications · 2025Article
- Lineage tracing in human tissues.The Journal of pathology · 2022Review
- Colorectal Cancer Progression Is Potently Reduced by a Glucose-Free, High-Protein Diet: Comparison to Anti-EGFR Therapy.Cancers · 2021Article
- The Histochemical Alterations of Mucin in Colorectal Carcinoma Quantified by Two Efficient Algorithms of Digital Image Analysis.International journal of molecular sciences · 2019Article
- Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.Cell stem cell · 2018Article
- Mucin expression patterns in histological grades of colonic cancers in Ghanaian population.The Pan African medical journal · 2017Article
- High-fat diet alters the oligosaccharide chains of colon mucins in mice.Histochemistry and cell biology · 2014Article
- Proximal versus distal hyperplastic polyps of the colorectum: different lesions or a biological spectrum?Journal of clinical pathology · 2004Article
- Reduction of sialic acid O-acetylation in human colonic mucins in the adenoma-carcinoma sequence.Glycoconjugate journal · 1999Article
- Article
- Correlative histochemical study providing evidence for the dual nature of human colorectal cancer mucin.The Histochemical journal · 1997Article
- Mucin staining.Journal of clinical pathology · 1996Article
- Mucin glycoproteins in neoplasia.Glycoconjugate journal · 1996Review
- Histochemical alterations of mucin in normal colon, inflammatory bowel disease and colonic adenocarcinoma.The Histochemical journal · 1995Article
- How selective are the 'selective periodate oxidation' methods used in sialic acid histochemistry?The Histochemical journal · 1991Article
- Histochemical identification of 9-O-acyl sialic acids: studies of bovine submandibular and rat sublingual gland and human colon.The Histochemical journal · 1991Article
- Sialic acid histochemistry and the adenoma-carcinoma sequence in colorectum.Journal of clinical pathology · 1990Article
- Colonic mucus and colitis.Gut · 1990Article
- Crypt restricted heterogeneity of goblet cell mucus glycoprotein in histologically normal human colonic mucosa: a potential marker of somatic mutation.British journal of cancer · 1990Article
- Histochemical studies of intestinal epithelial goblet cell glycoproteins during the development of the human foetus.The Histochemical journal · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucus secreted by colorectal cancer differs in three respects from that produced normally: an overall reduction, a loss of O-acetyl substituents in sialic acid, and an increase in neutral mucin. Similar changes have been reported in apparently normal mucosa bordering colorectal cancer. "Normal" left sided colorectal mucosa from 32 patients with rectal cancer was studied. Each case was matched by age and sex to a patient with diverticular disease and a patient with irritable bowel syndrome. Twenty five patients with right sided cancer were matched to patients with Crohn's disease. Sections were stained with mild periodic acid Schiff (mPAS) (selectively stains N-acetyl sialic acid lacking in O-acetyl group) and other closely related techniques. Reactions were graded negative, weak, and intense. An intense reaction was found in 9% of cases; there was no difference between the various matched groups. Phenylhydrazine interposition failed to block the mPAS effect, indicating that a positive result was due to a deficiency of sialic acid with O-acetyl substituents rather than neutral mucin. Different staining patterns in left and right colon were probably due to differing ratios of total sialic acid:fucose. These findings indicate a hitherto unsuspected colorectal goblet cell sialomucin heterogeneity within the general population, but no association with neoplastic disease is apparent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.