ArticleThe Journal of clinical investigation1986
Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia.
Article in The Journal of clinical investigation, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 82 citations in OpenAlex.
- Lipoproteins, cholesterol homeostasis and cardiac health.International journal of biological sciences · 2009Review
- Abetalipoproteinemia: two case reports and literature review.Orphanet journal of rare diseases · 2008Review
- Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase.The Biochemical journal · 1999Article
- Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice.The Journal of clinical investigation · 1999Article
- Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Control of Hep G2-cell triacylglycerol and apolipoprotein B synthesis and secretion by polyunsaturated non-esterified fatty acids and insulin.The Biochemical journal · 1992Article
- Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Effect of intestinal chylomicron secretory blockade on apolipoprotein synthesis in the newborn piglet.The Biochemical journal · 1992Article
- Measurement of de novo hepatic lipogenesis in humans using stable isotopes.The Journal of clinical investigation · 1991Article
- Anderson's disease: genetic exclusion of the apolipoprotein-B gene in two families.The Journal of clinical investigation · 1991Article
- Exclusion of linkage between the human apolipoprotein B gene and abetalipoproteinemia.American journal of human genetics · 1990Article
- Genetic evidence from two families that the apolipoprotein B gene is not involved in abetalipoproteinemia.The Journal of clinical investigation · 1988Article
- Truncated variants of apolipoprotein B cause hypobetalipoproteinaemia.Nucleic acids research · 1988Article
- Homozygous hypobetalipoproteinemia: a disease distinct from abetalipoproproteinemia at the molecular level.The Journal of clinical investigation · 1988Article
- Diagnosis of genetic disease using recombinant DNA. Supplement.Human genetics · 1987Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The apolipoprotein B-100 (apoB-100) gene in leukocytes and the apoB-100 messenger RNA (mRNA) and translated apolipoprotein in the livers from normal and abetalipoproteinemic individuals were evaluated. Four complementary DNA probes for apoB-100 covering the 5', middle, and 3' regions of the apoB-100 mRNA were utilized and Southern blot analysis indicated that the apoB-100 gene is present in abetalipoproteinemia without major insertions or deletions. Polyadenylated hepatic apoB-100 mRNA from two abetalipoproteinemic patients was normal in size, and the concentration of apoB-100 mRNA was increased sixfold compared with control hepatic apoB-100 mRNA levels. ApoB-100 was detected in hepatocytes of abetalipoproteinemic patients by immunohistochemical techniques. These results indicate that the biochemical defect in abetalipoproteinemic patients studied is most consistent with a posttranslational defect in apoB-100 processing or secretion with an up-regulation of the apoB-100 mRNA.
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