ArticleScience (New York, N.Y.)2023
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex.
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Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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88citing papers in PubMed
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88 citing papers in PubMed.
- Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions.Nature neuroscience · 2026Article
- Distinct single-nucleus RNA-seq changes among non-neuronal cells in ADNC, LATE-NC, and mixed pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Regional specialization of upper-layer inhibitory interneuron organization in the human prefrontal cortex.Journal of anatomy · 2026Article
- Mouse to Human Cross-Species Transfer Learning for Electrophysiology-to-Transcriptomics Mapping in Cortical GABAergic Interneurons.Neuroinformatics · 2026Article
- An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.Nature cell biology · 2026Article
- Transcriptional Profiles of Somatostatin and Parvalbumin Interneuron Subtypes in the Human Dorsolateral Prefrontal Cortex: Implications for Schizophrenia.The American journal of psychiatry · 2026Article
- Single-Nucleus Transcriptomics of the Mouse Medial Preoptic Area Reveals Sex-Dependent Molecular Signatures of Social Dominance.bioRxiv : the preprint server for biology · 2026Article
- Early postnatal DNA methylation dynamics define neuronal subtypes and are disrupted by MECP2 loss.bioRxiv : the preprint server for biology · 2026Article
- Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.Nature methods · 2026Article
- Combined patch-clamp electrophysiology and single-cell genomic analysis reveal spiking tumor cells at the neocortical glioblastoma interface in humans.Neuro-oncology · 2026Article
- Hypoactivity, abnormal development of dendrites relevant to impaired synaptic transmission of calretinin-expressing interneurons in the medial prefrontal cortex underlies social deficits of mouse model in autism.Translational psychiatry · 2026Article
- Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Repeated TLR7 activation induces cell type- and brain region-specific transcriptome changes in male mice.Scientific reports · 2026Article
- Conserved Kir channel mechanisms governing intrinsic excitability in human and rodent parvalbumin neurons.Communications biology · 2026Article
- Cellular Diversity Underpins Cortical Organization and Disease Vulnerability in the Human Brain.Neuroscience bulletin · 2026Article
- Transport-related effects on intrinsic and synaptic properties of human cortical neurons: A comparative study.The Journal of physiology · 2026Article
- Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum.bioRxiv : the preprint server for biology · 2026Article
- Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: From operating room to wet lab.Epilepsia open · 2026Article
- HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species.Communications biology · 2026Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
101 authors.
Brian R Lee *Allen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3210-5638
Rachel Dalley *Allen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-7461-7845
Jeremy A MillerAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-4549-588X
Thomas ChartrandAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-7093-8681
Jennie CloseAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9234-5855
Rusty MannAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-0226-2069
Alice MukoraAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-8431-985X
Lindsay NgAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-4134-1608
Lauren AlfilerAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-4847-7900
Katherine BakerAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-5454-8026
Darren BertagnolliAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-6626-1567
Krissy BrounerAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-5790-7154
Tamara CasperAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-1638-3651
Eva CsajbokMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, 6726 Szeged, Hungary.ORCID 0000-0002-7089-5431
Nicholas DonadioAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-6250-1148
Stan L W DriessensDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, 1081 HV, Netherlands.
Tom EgdorfAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9059-8904
Rachel EnstromAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-0100-927X
Anna A GalakhovaDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, 1081 HV, Netherlands.ORCID 0000-0002-5538-0624
Amanda GaryAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-6397-1520
Emily GelfandAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-2175-5894
Jeff GoldyAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-5140-6922
Kristen HadleyAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-4504-8724
Tim S HeistekDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, 1081 HV, Netherlands.
Dijon HillAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-8879-2476
Wen-Hsien HouDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Nelson JohansenAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-4436-969X
Nik JorstadAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-7906-9470
Lisa KimAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3811-8680
Agnes Katalin KocsisMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, 6726 Szeged, Hungary.ORCID 0000-0003-0810-5694
Lauren KruseAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3428-2443
Michael KunstAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-4159-8056
Gabriela LeónAllen Institute for Brain Science, Seattle, WA 98109, USA.
Brian LongAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-7793-5969
Matthew MalloryAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-8744-3837
Michelle MaxwellAllen Institute for Brain Science, Seattle, WA 98109, USA.
Medea McGrawAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-5267-489X
Delissa McMillenAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3413-4424
Erica J MeliefDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-3570-3289
Gabor MolnarMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, 6726 Szeged, Hungary.ORCID 0000-0001-7959-139X
Marty T MortrudAllen Institute for Brain Science, Seattle, WA 98109, USA.
Dakota NewmanAllen Institute for Brain Science, Seattle, WA 98109, USA.
Julie NyhusAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-2006-8235
Ximena Opitz-ArayaAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-4960-3622
Attila OzsvárDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Trangthanh PhamAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-4738-5062
Alice PomAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9057-040X
Lydia PotekhinaAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-8879-7920
Ram RajanbabuAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-7891-7578
Augustin RuizAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-8361-5152
Susan M SunkinAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9893-3834
Ildikó SzötsMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, 6726 Szeged, Hungary.ORCID 0000-0002-8564-4379
Naz TaskinAllen Institute for Brain Science, Seattle, WA 98109, USA.
Bargavi ThyagarajanAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3871-6410
Michael TieuAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9286-5623
Jessica TrinhAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-5064-8898
Sara VargasAllen Institute for Brain Science, Seattle, WA 98109, USA.
David VumbacoAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-8115-3081
Femke WaleboerDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, 1081 HV, Netherlands.ORCID 0000-0001-6170-5571
Sarah Walling-BellAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-6995-2681
Natalie WeedAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-0891-0327
Grace WilliamsAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-8463-2886
Julia WilsonAllen Institute for Brain Science, Seattle, WA 98109, USA.
Shenqin YaoAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-2992-4752
Thomas ZhouAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0009-0008-1589-8059
Pál BarzóDepartment of Neurosurgery, University of Szeged, 6725 Szeged, Hungary.ORCID 0000-0001-8717-748X
Trygve BakkenAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3373-7386
Charles CobbsSwedish Neuroscience Institute, Seattle, WA 98122, USA.ORCID 0000-0001-7688-4293
Nick DeeAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-2831-9254
Richard G EllenbogenDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-3463-1009
Luke EspositoAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3565-9126
Manuel FerreiraDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.
Nathan W GouwensAllen Institute for Brain Science, Seattle, WA 98109, USA.
Benjamin GrannanDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-6029-2821
Ryder P GwinnSwedish Neuroscience Institute, Seattle, WA 98122, USA.ORCID 0000-0002-5849-7975
Jason S HauptmanDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.
Rebecca HodgeAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-5784-9668
Tim JarskyAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-4399-539X
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5291-1469
Andrew L KoDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-6253-9891
Anders Rosendal KorshoejDepartment of Neurosurgery, Aarhus University Hospital, 8200 Aarhus, Denmark.ORCID 0000-0003-4285-8171
Boaz P LeviAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-8346-872X
Kaare MeierDepartment of Neurosurgery, Aarhus University Hospital, 8200 Aarhus, Denmark.ORCID 0000-0001-7677-406X
Jeffrey G OjemannDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-7580-8934
Anoop PatelDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.
Jacob RuzevickDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.
Daniel L SilbergeldDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.
Kimberly SmithAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3142-1970
Jens Christian SørensenDepartment of Neurosurgery, Aarhus University Hospital, 8200 Aarhus, Denmark.ORCID 0000-0001-5139-7405
Jack WatersAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-2312-4183
Hongkui ZengAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-0326-5878
Jim BergAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3300-5399
Marco CapognaDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-2742-5485
Natalia A GoriounovaDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, 1081 HV, Netherlands.ORCID 0000-0002-5917-983X
Brian KalmbachAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3136-8097
Christiaan P J de KockDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, 1081 HV, Netherlands.ORCID 0000-0002-6697-0179
Huib D MansvelderDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, 1081 HV, Netherlands.ORCID 0000-0003-1365-5340
Staci A SorensenAllen Institute for Brain Science, Seattle, WA 98109, USA.
Gabor TamasMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, 6726 Szeged, Hungary.ORCID 0000-0002-7905-6001
Ed S LeinAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9012-6552
Jonathan T TingAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-8266-0392
Funding
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0MA multimodal atlas of human brain cell typesU01MH114812 · NIMH · ALLEN INSTITUTE · PI LEIN, ED · 2017 to 2021
$19.2MDevelopment of tools for cell-type specific labeling of human and mouse neocortical neuronsRF1MH114126 · NIMH · ALLEN INSTITUTE · PI LEIN, ED, LEVI, BOAZ PIRIE · 2017 to 2017
$4.5MCell type selective viral tools to interrogate and correct non-human primate and human brain circuitryUG3MH120095 · NIMH · ALLEN INSTITUTE · PI KALUME, FRANCK K, LEIN, ED · 2020 to 2022
$3.8MMozak: Creating an Expert Community to accelerate neuronal reconstruction at scaleR01MH116247 · NIMH · UNIVERSITY OF WASHINGTON · PI POPOVIC, ZORAN · 2018 to 2022
$3.1MScalable tools for consistent identification of neuronal cell types in mouse and humanRF1MH128778 · NIMH · ALLEN INSTITUTE · PI SORENSEN, STACI A, SUMBUL, UYGAR · 2021 to 2021
$1.1MNIMH NIH HHS R01 MH116247NIMH NIH HHS RF1 MH114126NIMH NIH HHS RF1 MH128778NIMH NIH HHS U01 MH114812NIMH NIH HHS UG3 MH120095
Abstract
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid-producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling plus Patch-seq (patch-clamp electrophysiology plus single-cell RNA sequencing) sampling in human brain slices was used to reliably target and analyze GABAergic neuron subclasses and individual transcriptomic types. This characterization elucidated transitions between PVALB and SST subclasses, revealed morphological heterogeneity within an abundant transcriptomic type, identified multiple spatially distinct types of the primate-specialized double bouquet cells (DBCs), and shed light on cellular differences between homologous mouse and human neocortical GABAergic neuron types. These results highlight the importance of multimodal phenotypic characterization for refinement of emerging transcriptomic cell type taxonomies and for understanding conserved and specialized cellular properties of human brain cell types.
Indexed as
GABAergic NeuronsInterneuronsNeocortexAnimalsElectrophysiological Phenomenagamma-Aminobutyric AcidHumansMicePatch-Clamp Techniquesgamma-Aminobutyric Acid
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