Evidence map›Paper›PMID 37824668›Full record

ArticleScience (New York, N.Y.)2023

Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.

Filiz Sila Rizalar, Max T Lucht, Astrid Petzoldt, Shuhan Kong, Jiachen Sun, James H Vines, Narasimha Swamy Telugu, Sebastian Diecke, Thomas Kaas, Torsten Bullmann and 8 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. A PI(3,5)PNature communications · 2026
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  12. Biogenesis and reformation of synaptic vesicles.The Journal of physiology · 2025
    Review
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  15. Article
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  19. Article
  20. Generation of Glutamatergic Human Neurons from Induced Pluripotent Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Filiz Sila RizalarLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0002-9103-4681
Max T Lucht *Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0001-5785-3889
Astrid Petzoldt *Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0002-4059-7142
Shuhan KongLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Jiachen SunDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-0278-6831
James H VinesSchool of Biosciences, University of Sheffield, Firth Court Western Bank, Sheffield S10 2TN, UK.
Narasimha Swamy TeluguMax-Delbrück-Centrum für Molekulare Medizin (MDC), Technology Platform Pluripotent Stem Cells, 13125 Berlin, Germany.ORCID 0000-0003-4509-7056
Sebastian DieckeMax-Delbrück-Centrum für Molekulare Medizin (MDC), Technology Platform Pluripotent Stem Cells, 13125 Berlin, Germany.ORCID 0000-0002-5219-5992
Thomas KaasCarl-Ludwig Institute of Physiology, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0001-5281-9032
Torsten BullmannCarl-Ludwig Institute of Physiology, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0001-6637-0221
Christopher SchmiedLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0003-2058-1124
Delia LöweLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Jason S KingSchool of Biosciences, University of Sheffield, Firth Court Western Bank, Sheffield S10 2TN, UK.ORCID 0000-0003-0596-4506
Wonhwa ChoDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.
Stefan HallermannCarl-Ludwig Institute of Physiology, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0001-9376-7048
Dmytro PuchkovLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0001-8341-4847
Stephan J SigristDepartment of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0002-1698-5815
Volker HauckeLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0003-3119-6993
Leibniz-Forschungsinstitut für Molekulare Pharmakologie · DELeipzig University · DEFreie Universität Berlin · DEMax Delbrück Center · DEUniversity of Illinois Chicago · USUniversity of Sheffield · GB

Funding

Supplement for Equipment for Lipid Regulation of Cellular Signaling and Protein-Protein InteractionsR35GM122530 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WONHWA CHO · 2017 to 2026
$6.1M
NIGMS NIH HHS R35 GM122530
6 · The paper itself

Abstract

Neurons relay information via specialized presynaptic compartments for neurotransmission. Unlike conventional organelles, the specialized apparatus characterizing the neuronal presynapse must form de novo. How the components for presynaptic neurotransmission are transported and assembled is poorly understood. Our results show that the rare late endosomal signaling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P

Indexed as

Axonal TransportNeuronsPhosphatidylinositol PhosphatesSynaptic VesiclesHumansKinesinsKIF1A protein, humanKinesinsphosphatidylinositol 3,5-diphosphatePhosphatidylinositol Phosphates

Identifiers

PMID37824668
PMCPMC10938084
OpenAlexW4387568566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.