ArticleScience (New York, N.Y.)2023
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex.
Open access · greenAbstract readComparative Study
In one paragraph
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 78 citations in OpenAlex.
- The misplaced mouse Pax6 interneuron subclass: A cross-species transcriptomic reassignment.iScience · 2026Article
- A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions.Nature neuroscience · 2026Article
- Distinct single-nucleus RNA-seq changes among non-neuronal cells in ADNC, LATE-NC, and mixed pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.Nature cell biology · 2026Article
- Multimodal atlas of single neuron metabolic electrophysiological coupling uncovers circadian rewiring.iScience · 2026Article
- Conserved Kir channel mechanisms governing intrinsic excitability in human and rodent parvalbumin neurons.Communications biology · 2026Article
- Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum.bioRxiv : the preprint server for biology · 2026Article
- Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species.Communications biology · 2026Article
- Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling.bioRxiv : the preprint server for biology · 2026Article
- GABAergic neurons exhibit subtype-specific changes in the developing somatosensory cortex of a rat model of Fragile X Syndrome.Frontiers in neuroscience · 2026Article
- Biophysical modeling of thalamocortical circuit dynamics: species-specific insights into neural synchrony, sleep spindles, and circuit mechanisms.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex.Frontiers in synaptic neuroscience · 2026Article
- New directions for complex systems in contemporary neuroscience: a morphodynamic and emergent function approach.Frontiers in computational neuroscience · 2026Review
- Unique Transcriptomic Cell Types of the Granular Retrosplenial Cortex Are Preserved across Mice and Rats despite Dramatic Changes in Key Marker Genes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mapping human brain cell type origin and diseases through single-cell transcriptomics.Translational psychiatry · 2025Review
- Two- and three-dimensional neuropeptidomic landscape in the central nervous system of an invertebrate chordate,iScience · 2025Article
- RNA-programmable cell-type monitoring and manipulation in the human cortex with CellREADR.Cell reports · 2025Article
- Of mice and men: Dendritic architecture differentiates human from mouse neuronal networks.iScience · 2025Article
- MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
90 authors at 5 institutions in 3 countries.
Thomas ChartrandAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7093-8681
Rachel DalleyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-7461-7845
Jennie CloseAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9234-5855
Natalia A GoriounovaCenter for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, Netherlands.ORCID 0000-0002-5917-983X
Brian R LeeAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3210-5638
Rusty MannAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0226-2069
Jeremy A MillerAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-4549-588X
Gabor MolnarResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.ORCID 0000-0001-7959-139X
Alice MukoraAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8431-985X
Lauren AlfilerAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-4847-7900
Katherine BakerAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-5454-8026
Trygve E BakkenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3373-7386
Jim BergAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3300-5399
Darren BertagnolliAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6626-1567
Thomas Braunbyte physics, Berlin, Germany.ORCID 0000-0002-1416-2065
Krissy BrounerAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5790-7154
Tamara CasperAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-1638-3651
Eva Adrienn CsajbokResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.ORCID 0000-0002-7089-5431
Nick DeeAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-2831-9254
Tom EgdorfAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9059-8904
Rachel EnstromAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-0100-927X
Anna A GalakhovaCenter for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, Netherlands.ORCID 0000-0002-5538-0624
Amanda GaryAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6397-1520
Emily GelfandAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-2175-5894
Jeff GoldyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5140-6922
Kristen HadleyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4504-8724
Tim S HeistekCenter for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, Netherlands.
DiJon HillAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8879-2476
Nik JorstadAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-7906-9470
Lisa KimAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3811-8680
Agnes Katalin KocsisResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.ORCID 0000-0003-0810-5694
Lauren KruseAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3428-2443
Michael KunstAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-4159-8056
Gabriela LeonAllen Institute for Brain Science, Seattle, WA, USA.
Brian LongAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7793-5969
Matthew MalloryAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8744-3837
Medea McGrawAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5267-489X
Delissa McMillenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3413-4424
Erica J MeliefDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3570-3289
Norbert MihutResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.
Lindsay NgAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4134-1608
Julie NyhusAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-2006-8235
Gáspár OláhResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.ORCID 0000-0003-4708-2368
Attila OzsvárResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.
Victoria OmsteadAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3796-970X
Zoltan PeterfiResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.
Alice PomAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9057-040X
Lydia PotekhinaAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8879-7920
Ramkumar RajanbabuAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7891-7578
Marton RozsaResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.ORCID 0000-0003-3547-0750
Augustin RuizAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8361-5152
Joanna SandleResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.
Susan M SunkinAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9893-3834
Ildiko SzotsResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.ORCID 0000-0002-8564-4379
Michael TieuAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9286-5623
Martin TothResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.ORCID 0000-0001-5973-0401
Jessica TrinhAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-5064-8898
Sara VargasAllen Institute for Brain Science, Seattle, WA, USA.
David VumbacoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8115-3081
Grace WilliamsAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8463-2886
Julia WilsonAllen Institute for Brain Science, Seattle, WA, USA.
Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-9361-5607
Pal BarzoDepartment of Neurosurgery, University of Szeged, Szeged, Hungary.ORCID 0000-0001-8717-748X
Charles CobbsSwedish Neuroscience Institute, Seattle, WA, USA.ORCID 0000-0001-7688-4293
Richard G EllenbogenDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3463-1009
Luke EspositoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3565-9126
Manuel FerreiraDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Nathan W GouwensAllen Institute for Brain Science, Seattle, WA, USA.
Benjamin GrannanDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6029-2821
Ryder P GwinnSwedish Neuroscience Institute, Seattle, WA, USA.ORCID 0000-0002-5849-7975
Jason S HauptmanDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Tim JarskyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4399-539X
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5291-1469
Andrew L KoDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6253-9891
Christof KochAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-6482-8067
Jeffrey G OjemannDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7580-8934
Anoop PatelDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Jacob RuzevickDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Daniel L SilbergeldDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Kimberly SmithAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3142-1970
Staci A SorensenAllen Institute for Brain Science, Seattle, WA, USA.
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6861-4506
Jonathan T TingAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8266-0392
Jack WatersAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-2312-4183
Christiaan P J de KockCenter for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, Netherlands.ORCID 0000-0002-6697-0179
Huib D MansvelderCenter for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, Netherlands.ORCID 0000-0003-1365-5340
Gabor TamasResearch Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.ORCID 0000-0002-7905-6001
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0326-5878
Brian Kalmbach *Allen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3136-8097
Ed S Lein *Allen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9012-6552
Allen Institute for Brain Science · USUniversity of Szeged · HUUniversity of Washington · USVrije Universiteit Amsterdam · NLSwedish Medical Center · US
Funding
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0MA multimodal atlas of human brain cell typesU01MH114812 · NIMH · ALLEN INSTITUTE · PI LEIN, ED · 2017 to 2021
$19.2MMozak: Creating an Expert Community to accelerate neuronal reconstruction at scaleR01MH116247 · NIMH · UNIVERSITY OF WASHINGTON · PI POPOVIC, ZORAN · 2018 to 2022
$3.1MScalable tools for consistent identification of neuronal cell types in mouse and humanRF1MH128778 · NIMH · ALLEN INSTITUTE · PI SORENSEN, STACI A, SUMBUL, UYGAR · 2021 to 2021
$1.1MNIMH NIH HHS R01 MH116247NIMH NIH HHS RF1 MH128778NIMH NIH HHS U01 MH114812
Abstract
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 interneurons are similarly diverse is underexplored. Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1. Subclass and subtype comparisons showed stronger transcriptomic differences in human L1 and were correlated with strong morphoelectric variability along dimensions distinct from mouse L1 variability. Accompanied by greater layer thickness and other cytoarchitecture changes, these findings suggest that L1 has diverged in evolution, reflecting the demands of regulating the expanded human neocortical circuit.
Indexed as
NeocortexAnimalsAxonsHumansInterneuronsMicePyramidal CellsTranscriptome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.