ArticleScience (New York, N.Y.)2023
Comparative transcriptomics reveals human-specific cortical features.
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Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.
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140citing papers in PubMed, 1 pooled it
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Who cites it
140 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of single-cell RNA sequencing co-expression in human neural organoids reveals their high variability in recapitulating primary tissue.PLoS biology · 2024Pooled it
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- A systematic assessment of single-cell language model configurations.NAR genomics and bioinformatics · 2026Article
- A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions.Nature neuroscience · 2026Article
- The compositionality continuum as a principle for studying the neural basis of intelligence.Nature neuroscience · 2026Review
- Distinct single-nucleus RNA-seq changes among non-neuronal cells in ADNC, LATE-NC, and mixed pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Regional specialization of upper-layer inhibitory interneuron organization in the human prefrontal cortex.Journal of anatomy · 2026Article
- An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.Nature cell biology · 2026Article
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- A Role for Astrocyte Metabolism in Species-Specific Neuronal Development.bioRxiv : the preprint server for biology · 2026Article
- CroCoNet: a framework for the quantitative comparison of gene regulatory networks across species.Genome biology · 2026Article
- Developmental signaling reveals functionally enriched human-specific gene regulation in telencephalic progenitors.bioRxiv : the preprint server for biology · 2026Article
- Dendritic morphology and synaptic nonlinearities enhance functional complexity in human cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Positive selection on brain cis-regulatory elements in the human lineage drives changes in gene expression and susceptibility to neuropsychiatric disorders.HGG advances · 2026Article
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- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- Widespread synaptic density loss in schizophrenia follows molecular and network architecture.Molecular psychiatry · 2026Article
80 more citing papers are in PubMed but not listed here.
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Authors and funding
44 authors.
Nikolas L Jorstad *Allen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-7906-9470
Janet H T Song *Allen Discovery Center for Human Brain Evolution, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7898-0227
David Exposito-Alonso *Allen Discovery Center for Human Brain Evolution, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4950-2744
Hamsini SureshCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.ORCID 0000-0001-9133-1929
Nathan Castro-PachecoCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.ORCID 0009-0000-3645-3704
Fenna M KrienenDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1400-6820
Anna Marie YannyAllen Institute for Brain Science, Seattle, WA 98109, USA.
Jennie CloseAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9234-5855
Emily GelfandAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-2175-5894
Brian LongAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-7793-5969
Stephanie C SeemanAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3894-1992
Kyle J TravagliniAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3164-6448
Soumyadeep BasuLKEB, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-8918-9203
Marc BeaudinAllen Discovery Center for Human Brain Evolution, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0000-0657-7650
Darren BertagnolliAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-6626-1567
Megan CrowCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.ORCID 0000-0002-1172-5897
Song-Lin DingAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-7072-5272
Jeroen EggermontLKEB, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0003-0361-9469
Alexandra GlandonAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-1539-3332
Jeff GoldyAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-5140-6922
Katelyn KiickAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-1785-8092
Thomas KroesLKEB, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-0658-2203
Delissa McMillenAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3413-4424
Trangthanh PhamAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-4738-5062
Christine RimorinAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-1491-8552
Kimberly SilettiDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7620-8973
Saroja SomasundaramAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3729-9849
Michael TieuAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9286-5623
Amy TorkelsonAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-9465-4202
Guoping FengMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
William D HopkinsKeeling Center for Comparative Medicine and Research, University of Texas, MD Anderson Cancer Center, Houston, TX 78602, USA.
Thomas HölltComputer Graphics and Visualization Group, Delft University of Technology, Delft, Netherlands.ORCID 0000-0001-8125-1650
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5291-1469
Sten LinnarssonDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-3491-3444
Steven A McCarrollDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6954-8184
Boudewijn P LelieveldtLKEB, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-8269-7603
Chet C SherwoodDepartment of Anthropology, The George Washington University, Washington, DC 20037, USA.ORCID 0000-0001-6711-449X
Kimberly SmithAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3142-1970
Christopher A WalshAllen Discovery Center for Human Brain Evolution, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0156-2238
Alexander DobinCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.ORCID 0000-0002-4115-9128
Jesse GillisDepartment of Physiology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-0936-9774
Ed S LeinAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9012-6552
Rebecca D HodgeAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-5784-9668
Trygve E BakkenAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3373-7386
Funding
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7MTool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI ARLOTTA, PAOLA, HUANG, Z JOSH · 2017 to 2021
$64.5MA multimodal atlas of human brain cell typesU01MH114812 · NIMH · ALLEN INSTITUTE · PI LEIN, ED · 2017 to 2021
$19.2MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MA Molecular and Cellular Atlas of the Marmoset BrainU01MH114819 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FENG, GUOPING · 2017 to 2021
$6.9MNovel algorithm development, user support and maintenance for STARR01HG009318 · NHGRI · COLD SPRING HARBOR LABORATORY · PI DOBIN, ALEXANDER · 2017 to 2021
$2.4MComparative Epigenomics of Primate BrainsR01HG011641 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI KONOPKA, GENEVIEVE, SHERWOOD, CHESTER · 2021 to 2024
$2.4MRevealing the transcriptomic basis of neuronal identity through functional meta-analysisR01MH113005 · NIMH · COLD SPRING HARBOR LABORATORY · PI GILLIS, JESSE · 2017 to 2021
$2.4MHeuristics to evaluate biomedical and genomic knowledge bases for validityR01LM012736 · NLM · COLD SPRING HARBOR LABORATORY · PI GILLIS, JESSE · 2017 to 2020
$1.9MA National Chimpanzee Brain ResourceR24NS092988 · NINDS · GEORGE WASHINGTON UNIVERSITY · PI SHERWOOD, CHESTER · 2015 to 2018
$969kMeta-analysis to define neuronal diversity: from genes to functions across speciesF32MH114501 · NIMH · COLD SPRING HARBOR LABORATORY · PI CROW, MEGAN · 2017 to 2018
$111kNHGRI NIH HHS R01 HG009318NHGRI NIH HHS R01 HG011641NICHD NIH HHS P50 HD105351NIMH NIH HHS F32 MH114501NIMH NIH HHS R01 MH113005NIMH NIH HHS U01 MH114812NIMH NIH HHS U01 MH114819NIMH NIH HHS U19 MH114821NIMH NIH HHS U19 MH114830NINDS NIH HHS R24 NS092988NLM NIH HHS R01 LM012736
Abstract
The cognitive abilities of humans are distinctive among primates, but their molecular and cellular substrates are poorly understood. We used comparative single-nucleus transcriptomics to analyze samples of the middle temporal gyrus (MTG) from adult humans, chimpanzees, gorillas, rhesus macaques, and common marmosets to understand human-specific features of the neocortex. Human, chimpanzee, and gorilla MTG showed highly similar cell-type composition and laminar organization as well as a large shift in proportions of deep-layer intratelencephalic-projecting neurons compared with macaque and marmoset MTG. Microglia, astrocytes, and oligodendrocytes had more-divergent expression across species compared with neurons or oligodendrocyte precursor cells, and neuronal expression diverged more rapidly on the human lineage. Only a few hundred genes showed human-specific patterning, suggesting that relatively few cellular and molecular changes distinctively define adult human cortical structure.
Indexed as
CognitionHominidaeNeocortexTemporal LobeAnimalsGene Expression ProfilingGorilla gorillaHumansMacaca mulattaPan troglodytesPhylogenySpecies SpecificityTranscriptome
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