ArticleScience advances2023
Daily turnover of active giant virus infection during algal blooms revealed by single-cell transcriptomics.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Molecular and cellular insights into the parasitic infection of bloom-forming marine diatoms by Pirsonia diadema.Nature microbiology · 2026Article
- Inferring single-cell heterogeneity of bacteriophage lysis-associated life-history traits from population-scale dynamics.Science advances · 2026Article
- Latent endogenous giant viruses drive active infection and inheritance in a multicellular algal host.Nature microbiology · 2026Article
- Quantitative stable isotope probing (qSIP)-informed metagenomics identifies viruses infecting chemoautotrophs.Nature communications · 2026Article
- Revisiting giant virus-host dynamics in brown algae: old stories and new perspectives.The EMBO journal · 2026Review
- Diving into the hidden viral world of marine protists.Journal of virology · 2026Review
- Mapping of the viral shunt across widespread coccolithophore blooms using metabolic biomarkers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Viromics approaches for the study of viral diversity and ecology in microbiomes.Nature reviews. Genetics · 2026Review
- Illuminating the newly produced viruses within the virosphere with bioorthogonal noncanonical amino acid tagging and single-virus genomic sequencing technologies.ISME communications · 2026Article
- Article
- A single-cell perspective on host-virus dynamics in the ocean.Trends in microbiology · 2025Review
- Microorganisms in Macroalgae Cultivation Ecosystems: A Systematic Review and Future Prospects Based on Bibliometric Analysis.Microorganisms · 2025Review
- Unexpected diversity and ecological significance of uncultivable large virus-like particles in aquatic environments.ISME communications · 2025Article
- Complex transcriptional regulations of a hyperparasitic quadripartite system in giant viruses infecting protists.Nature communications · 2024Article
- The consequences of viral infection on protists.Communications biology · 2024Review
- Homing in on the rare virosphere reveals the native host of giant viruses.bioRxiv : the preprint server for biology · 2023Article
- Viral infection in the ocean-A journey across scales.PLoS biology · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giant viruses infect many unicellular eukaryotes, including algae that form massive oceanic blooms. Despite the major impact of viruses on the marine ecosystem, the ability to quantify and assess active viral infection in nature remains a major challenge. We applied single-cell RNA sequencing, to profile virus and host transcriptomes of 12,000 single algal cells from a coccolithophore bloom. Viral infection was detected already at early exponential bloom phase, negatively correlating with the bloom intensity. A consistent percent of infected coccolithophores displayed the early phase of viral replication for several consecutive days, indicating a daily turnover and continuous virocell-associated metabolite production, potentially affecting the surrounding microbiome. Linking single-cell infection state to host physiology revealed that infected cells remained calcified even in the late infection stage. These findings stress the importance of studying host-virus dynamics in natural populations, at single-cell resolution, to better understand virus life cycle and its impact on microbial food webs.
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