ArticleScience advances2023
Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies.
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Three Doses and Six Months Later: Real-World SARS-CoV-2 Specific Humoral and Cell-Mediated Immunity in Children With Inborn Errors of Immunity.Journal of clinical immunology · 2026Observational
- Breakthrough SARS-CoV-2 outcomes in immune-disordered people during the Omicron era: a prospective cohort study.BMJ public health · 2025Article
- Article
- Stuck in pandemic uncertainty: a review of the persistent effects of COVID-19 infection in immune-deficient people.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2024Review
- An Overview of the Strategies to Boost SARS-CoV-2-Specific Immunity in People with Inborn Errors of Immunity.Vaccines · 2024Review
- Humoral and cell-mediated immune responses to COVID-19 vaccines up to 6 months post three-dose primary series in adults with inborn errors of immunity and their breakthrough infections.Frontiers in immunology · 2024Observational
- Impact of Exposure to Vaccination and Infection on Cellular and Antibody Response to SARS-CoV-2 in CVID Patients Through COVID-19 Pandemic.Journal of clinical immunology · 2023Article
- Effects of Oregano Essential Oil on IgAAnimals : an open access journal from MDPI · 2023Article
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Authors and funding
47 authors at 11 institutions in 1 country.
Mackenzie ZendtLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0009-0008-6313-5777
Fausto A Bustos CarrilloLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-7263-5625
Sophie KellyTrans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH, Bethesda, MD, USA.ORCID 0000-0001-8350-3671
Taylor SaturdayLaboratory of Virology, DIR, NIAID, NIH, Hamilton, NY, USA.
Maureen DeGrangeLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0009-0009-9417-6990
Anita GinigemeLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0009-0007-3639-6034
Lurline WuLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Viviane CallierClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Ana Ortega-VillaBiostatistics Research Branch, Division of Clinical Research, NIAID, NIH, Rockville, MD, USA.ORCID 0000-0002-5589-9557
Mondreakest FaustSection for Immunoengineering, NIBIB, NIH, Bethesda, MD, USA.
Emma Chang-RableyLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-8652-909X
Kara BugalDivision of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
Heather KenneyLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Pavel KhilDivision of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.ORCID 0000-0002-4903-8777
Jung-Ho YounDivision of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
Gloria OseiDivision of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
Pravesh RegmiDivision of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
Victoria AndersonLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Marita BosticardoLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-1771-4523
Janine DaubLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Thomas DiMaggioLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-3051-5553
Samantha KreuzburgLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Francesca PalaLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0003-4537-9061
Justina PfisterLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0009-0008-3737-7393
Jennifer TreatLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Jean UlrickLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Maria KarkanitsaSection for Immunoengineering, NIBIB, NIH, Bethesda, MD, USA.ORCID 0000-0003-3474-2371
Heather KalishTrans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH, Bethesda, MD, USA.ORCID 0000-0002-4848-2067
Douglas B KuhnsLeidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-9971-0760
Debra L PrielLeidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-9434-4503
Danielle L FinkLeidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
John S TsangDepartment of Immunobiology and Yale Center for Systems and Engineering Immunology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3186-3047
Rachel SparksLaboratory of Immune System Biology, DIR, NIAID, NIH, Bethesda, MD,USA.ORCID 0000-0001-8216-5084
Gulbu UzelLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Meryl A WaldmanKidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.ORCID 0000-0001-8698-0502
Christa S ZerbeLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0003-4219-0503
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-4772-0799
Jenna R E BergersonLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Sanchita DasDivision of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.ORCID 0000-0002-2246-7942
Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0001-7005-8345
Michail S LionakisLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0003-4994-9500
Kaitlyn SadtlerSection for Immunoengineering, NIBIB, NIH, Bethesda, MD, USA.ORCID 0000-0003-2587-8330
Neeltje van DoremalenLaboratory of Virology, DIR, NIAID, NIH, Hamilton, NY, USA.ORCID 0000-0003-4368-6359
Vincent MunsterLaboratory of Virology, DIR, NIAID, NIH, Hamilton, NY, USA.ORCID 0000-0002-2288-3196
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-8335-0262
Steven M HollandLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0003-3207-5464
Emily E RicottaLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0001-9928-8275
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health Clinical Center · USNational Institutes of Health · USLeidos (United States) · USGE Global Research (United States) · USNational Institute of Biomedical Imaging and Bioengineering · USEnterprise Science and Computing (United States) · USFrederick National Laboratory for Cancer Research · USNational Institute of Diabetes and Digestive and Kidney Diseases · USOffice of Science · USYale University · US
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MImmune response to COVID-19 vaccination in individuals with immune disordersZIAAI001335 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RICOTTA, EMILY · 2021 to 2024
$1.8MCCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA AI001335NCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261200800001ENCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003I
Abstract
Research on coronavirus disease 2019 vaccination in immune-deficient/disordered people (IDP) has focused on cancer and organ transplantation populations. In a prospective cohort of 195 IDP and 35 healthy volunteers (HV), antispike immunoglobulin G (IgG) was detected in 88% of IDP after dose 2, increasing to 93% by 6 months after dose 3. Despite high seroconversion, median IgG levels for IDP never surpassed one-third that of HV. IgG binding to Omicron BA.1 was lowest among variants. Angiotensin-converting enzyme 2 pseudo-neutralization only modestly correlated with antispike IgG concentration. IgG levels were not significantly altered by receipt of different messenger RNA-based vaccines, immunomodulating treatments, and prior severe acute respiratory syndrome coronavirus 2 infections. While our data show that three doses of coronavirus disease 2019 vaccinations induce antispike IgG in most IDP, additional doses are needed to increase protection. Because of the notably reduced IgG response to Omicron BA.1, the efficacy of additional vaccinations, including bivalent vaccines, should be studied in this population.
Indexed as
COVID-19Immunoglobulin GCOVID-19 VaccinesHumansImmunityProspective StudiesCOVID-19 VaccinesImmunoglobulin G
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