ArticleScience advances2023
First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 35 citations in OpenAlex.
- PD-L1 PET/CT imaging withEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Coronary artery disease imaging with total-body PET.The British journal of radiology · 2026Review
- Kinetic modeling with total body PET-current status and future applications.The British journal of radiology · 2026Review
- Parametric imaging of dynamic long-axial-field-of-view PET scans: Technical challenges, statistical insights and clinical applications.Zeitschrift fur medizinische Physik · 2026Review
- ESR Innovation in Focus: Long-axial field-of-view PET/CT.European radiology · 2026Article
- Compartment-specific phase compensation between pulmonary T-Cell immunity and waning systemic responses in BA.5 breakthrough infection.Respiratory research · 2026Article
- Clinical nuclear medicine applications of zirconium-89 immuno-PET: a comprehensive review from a radiopharmaceutical perspective.EJNMMI radiopharmacy and chemistry · 2026Review
- Continuous bed motion versus step-and-shoot acquisition in LAFOV PET/CT: insights from multi-phantom and patient studies.EJNMMI physics · 2026Article
- Noninvasive Monitoring of Inflammatory Processes by Myeloid Cell-Directed PET Tracers in an Experimental Severe Acute Respiratory Syndrome Coronavirus 2 Infection Model.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Emerging ImmunoPET probes for precision cancer immunotherapy: molecular targets and translational applications.Frontiers in oncology · 2026Review
- Molecular contrast agents for post-infarct cardiac remodelling: a contemporary review.European heart journal. Imaging methods and practice · 2026Review
- LAFOV PET as an enabling platform for pharmacokinetics-informed digital twins.Frontiers in medicine · 2026Article
- Long Axial Field of View PET: A New Era of Quantitative PET Imaging for Prospective Applications Beyond Classical Theranostics.PET clinics · 2025Review
- A scoping review on potential of novel developments in fever of unknown origin and inflammation of unknown origin: long-axial-field-of-view positron emission tomography/computed tomography and novel radiotracers.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2025Article
- Total-body positron emission tomography imaging to accelerate radiotracer discovery pipelines.Pharmacological reviews · 2025Review
- Whole-body PET imaging of simian immunodeficiency virus using gp120-targeting probes fails to reveal regions of specific uptake in rhesus macaques.European journal of nuclear medicine and molecular imaging · 2025Article
- Exploring molecular imaging to investigate immune checkpoint inhibitor-related toxicity.Journal for immunotherapy of cancer · 2025Review
- Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook.Seminars in thrombosis and hemostasis · 2025Review
- Total Body PET/CT: Future Aspects.Seminars in nuclear medicine · 2025Review
- Advances and challenges in precision imaging.The Lancet. Oncology · 2025Review
Corrections and comments
- Update of
Authors and funding
13 authors at 4 institutions in 3 countries.
Negar OmidvariDepartment of Biomedical Engineering, University of California Davis, Davis, CA, USA.ORCID 0000-0002-7589-4745
Terry JonesDepartment of Radiology, University of California Davis Medical Center, Sacramento, CA, USA.ORCID 0000-0002-8852-6837
Pat M PriceDepartment of Surgery and Cancer, Imperial College London, London, UK.ORCID 0000-0003-4709-3323
April L FerreDepartment of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, USA.ORCID 0009-0003-5963-1309
Jacqueline LuDepartment of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, USA.
Yasser G AbdelhafezDepartment of Radiology, University of California Davis Medical Center, Sacramento, CA, USA.ORCID 0000-0002-1989-3094
Fatma SenDepartment of Radiology, University of California Davis Medical Center, Sacramento, CA, USA.
Stuart H CohenDivision of Infectious Diseases, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA, USA.
Kristin SchmiedehausenImaginAb Inc., Inglewood, CA, USA.
Ramsey D BadawiDepartment of Biomedical Engineering, University of California Davis, Davis, CA, USA.ORCID 0000-0002-9769-0292
Barbara L ShacklettDepartment of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, USA.ORCID 0000-0002-7067-732X
Ian WilsonImaginAb Inc., Inglewood, CA, USA.
Simon R CherryDepartment of Biomedical Engineering, University of California Davis, Davis, CA, USA.ORCID 0000-0002-0155-5644
University of California Davis Medical Center · USUniversity of California, Davis · USImaginAb (United States) · USImperial College London · GB
Funding
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9MEXPLORER: Changing the Molecular Imaging Paradigm with Total Body PETR01CA206187 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BADAWI, RAMSEY D., CHERRY, SIMON R · 2015 to 2019
$15.5MResearch at the interface of optical and ionizing radiation for innovative cancer imaging and therapyR35CA197608 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHERRY, SIMON R · 2015 to 2021
$4.9MUC Davis Shared Astrios Cell SorterS10OD018223 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHACKLETT, BARBARA L. · 2015 to 2015
$555kShared LSRII Cytometer Equipment Application - UC Davis Stem Cell ProgramS10RR026825 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NOLTA, JAN A. · 2010 to 2010
$500kNCI NIH HHS P30 CA093373NCI NIH HHS R01 CA206187NCI NIH HHS R35 CA197608NCRR NIH HHS S10 RR026825NIH HHS S10 OD018223
Abstract
With most of the T cells residing in the tissue, not the blood, developing noninvasive methods for in vivo quantification of their biodistribution and kinetics is important for studying their role in immune response and memory. This study presents the first use of dynamic positron emission tomography (PET) and kinetic modeling for in vivo measurement of CD8
Indexed as
COVID-19CD8-Positive T-LymphocytesCell Line, TumorHumansPositron-Emission TomographyTissue DistributionZirconiumZirconium
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.