Evidence map›Paper›PMID 37824394›Full record

ArticleCritical reviews in eukaryotic gene expression2024

K-Homology Type Splicing Regulatory Protein: Mechanism of Action in Cancer and Immune Disorders.

Jonathan D Leavenworth, Nabiha Yusuf, Quamarul Hassan

Open access · greenAbstract read
In one paragraph

Article in Critical reviews in eukaryotic gene expression, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jonathan D LeavenworthDepartment of Oral and Maxillofacial Surgery, Institute of Oral Health Research, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
Nabiha YusufDepartment of Dermatology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Quamarul HassanDepartment of Oral and Maxillofacial Surgery, Institute of Oral Health Research, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
Mechanisms elicited by type I interferons in cutaneous photocarcinogenesisR01AR071157 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YUSUF, NABIHA · 2016 to 2020
$1.8M
An Epigenetic Axis in Bone FormationR01AR069578 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HASSAN, QUAMARUL · 2016 to 2020
$1.6M
The Role of Baf45a in Bone FormationF30DE027280 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GODFREY, TANNER COLE · 2018 to 2021
$201k
NIAMS NIH HHS R01 AR069578NIAMS NIH HHS R01 AR071157NIDCR NIH HHS F30 DE027280NIDCR NIH HHS T90 DE022736
6 · The paper itself

Abstract

K homology-type splicing regulatory protein (KSRP) is emerging as a key player in cancer biology, and immunology. As a single-strand nucleic acid binding protein it functions in both transcriptional and post-transcriptional regulation, while facilitating multiple stages of RNA metabolism to affect proliferation and control cell fate. However, it must interact with other proteins to determine the fate of its bound substrate. Here we provide an minireview of this important regulatory protein and describe its complex subcellular functions to affect RNA metabolism, stability, miRNA biogenesis and maturation, stress granule function, metastasis, and inflammatory processes.

Indexed as

Immune System DiseasesNeoplasmsHumansRNARNA-Binding ProteinsTrans-ActivatorsTranscription FactorsRNARNA-Binding ProteinsTrans-ActivatorsTranscription Factors

Identifiers

PMID37824394
PMCPMC11003564
OpenAlexW4376851343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.