Evidence map›Paper›PMID 37823994›Full record

ArticleTropical animal health and production2023

Genome-wide association study reveals candidate genes for traits related to meat quality in Colombian Creole hair sheep.

Herman Alberto Revelo, Diana López-Alvarez, Yineth Alexandra Palacios, Oscar David Vergara, Moris Bustamante Yánez, Manuel Fernando Ariza, Susan Lorena Castro Molina, Yurany Ortiz Sanchez, Luz Ángela Alvarez

Open access · hybridAbstract read
In one paragraph

Article in Tropical animal health and production, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Application of GWAS and mGWAS in Livestock and Poultry Breeding.Animals : an open access journal from MDPI · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Herman Alberto ReveloGrupo de Investigación de Recursos Zoogenéticos, Departamento de Ciencia Animal, Facultad de Ciencias Agropecuarias, Universidad Nacional de Colombia, 763533, Palmira, Colombia. hareveloc@unal.edu.co.ORCID http://orcid.org/0000-0002-3193-3255
Diana López-AlvarezGrupo de Investigación de Recursos Zoogenéticos, Departamento de Ciencia Animal, Facultad de Ciencias Agropecuarias, Universidad Nacional de Colombia, 763533, Palmira, Colombia. dilopezal@unal.edu.co.
Yineth Alexandra PalaciosGrupo de Investigación de Recursos Zoogenéticos, Departamento de Ciencia Animal, Facultad de Ciencias Agropecuarias, Universidad Nacional de Colombia, 763533, Palmira, Colombia.
Oscar David VergaraGrupo de Investigación en Producción Animal Tropical, Universidad de Córdoba, 14014, Córdoba, Colombia.
Moris Bustamante YánezGrupo de Investigación en Producción Animal Tropical, Universidad de Córdoba, 14014, Córdoba, Colombia.
Manuel Fernando ArizaDepartment of Animal Production, Universidad Nacional de Colombia, 111321, Bogotá D.C, Colombia.
Susan Lorena Castro MolinaDepartment of Animal Production, Universidad Nacional de Colombia, 111321, Bogotá D.C, Colombia.
Yurany Ortiz SanchezDepartment of Animal Production, Universidad Nacional de Colombia, 111321, Bogotá D.C, Colombia.
Luz Ángela AlvarezGrupo de Investigación de Recursos Zoogenéticos, Departamento de Ciencia Animal, Facultad de Ciencias Agropecuarias, Universidad Nacional de Colombia, 763533, Palmira, Colombia.
Universidad Nacional de Colombia · COUniversity of Córdoba · COSaint Martin University · CO

Funding

Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS) 757
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) allow identifying genomic regions related to traits of economic importance in animals of zootechnical interest. The objective of this research was to conduct a genome-wide association study on meat quality traits using the Illumina OvineSNPs50 BeadChip array. The animals were sampled in the departments of Córdoba, Cesar, and Valle del Cauca. The genotypes obtained with the Illumina OvineSNP50 BeadChip microarray were analyzed SNP (single-nucleotide polymorphism) data to conduct a GWAS for pH and water-holding capacity (WHC) traits measured after 7 days of maturation, in the Longissimus dorsi (LD) muscle, in 167 Creole hair sheep of 12 months old belonging to Pelibuey (CHSP, n = 60), Ethiopian (CHSE, n = 44), and Sudan (CHSS, n = 63) breeds. The GWAS was done using a mixed linear model (MLMA) and based on the Ovis aries v3.1 genome. The CHSE showed the lowest meat juice release and, consequently, the highest water-holding capacity (WHC = 30.6 ± 0.1), suggesting that this breed has better performance in the meat industry compared with CHSS (WHC = 41.7 ± 0.1) and CHSP (WHC = 36.8 ± 0.1), since there is a relationship between WHC and juiciness. For the character pH, it was not possible to annotate genes related to meat quality, while, for the WHC, they have obtained 11 candidate genes associated (ELOVL2, ARAP2, LOC101102527, SHOC2, AIPL1, CSRNP3, IFRD, KDM8, NANS, DAPK1, IBN2, TPM2). Particularly, ELOVL2, ARAP2, IBN2, and TPM2 genes are involved in muscle contraction and fatty acid composition in sheep. In this study, we generated a baseline for GWAS related to meat quality traits in Colombian Creole hair sheep that can be used for future genomic selection plans.

Indexed as

Genome-Wide Association StudyMeatAnimalsColombiaPhenotypePolymorphism, Single NucleotideSheepWaterWaterCreole sheepGrowthGWASSNPs

Identifiers

PMID37823994
PMCPMC10570192
OpenAlexW4387564114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.