Evidence map›Paper›PMID 37823929›Full record

ArticleMedical molecular morphology2024

Morphological and etiological analyses of C3 and non-C3 glomerulonephritis in primary membranoproliferative glomerulonephritis using periodic acid-methenamine silver stain electron microscopy: a retrospective multicentered study.

Shiko Honma, Naomi Sato, Ryoko Sakaguchi, Akinori Hashiguchi, Noriko Uesugi, Yasuhiro Nakamura, Hironobu Sasano, Kensuke Joh

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Article in Medical molecular morphology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Shiko HonmaDepartment of Pathology, School of Medicine, The Jikei University, Tokyo, Japan.
Naomi SatoDepartment of Pathology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Ryoko SakaguchiDepartment of Pathology, School of Medicine, The Jikei University, Tokyo, Japan.
Akinori HashiguchiDepartment of Pathology, School of Medicine, Keio University, Tokyo, Japan.
Noriko UesugiDepartment of Pathology, Fukuoka University of Medicine, Fukuoka, Japan.
Yasuhiro NakamuraFaculty of Medicine, Division of Pathology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Hironobu SasanoDepartment of Pathology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kensuke JohDepartment of Pathology, School of Medicine, The Jikei University, Tokyo, Japan. johken@med.tohoku.ac.jp.ORCID http://orcid.org/0000-0002-9334-3664
Jikei University School of Medicine · JPTohoku University · JPFukuoka University · JPKeio University · JPTohoku Medical and Pharmaceutical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study elucidated the etiology of C3 glomerulonephritis (C3GN) and non-C3GN with primary membranoproliferative glomerulonephritis (MPGN) using transmission electron microscopy (TEM) and periodic acid-methenamine silver stain (PAM-EM). Thirty-one primary MPGN cases were analyzed by TEM and PAM-EM to distinguish among MPGN I, MPGN II, MPGN III Burkholder subtype (MPGN IIIB), and Anders and Strife subtype (MPGN IIIA/S). Each case was also classified into C3GN or non-C3GN according to the standard C3GN definition using immunostaining. Four cases of MPGN II met C3 glomerulopathy; whereas, four cases of MPGN IIIB did not meet C3 glomerulopathy. Seven of 11 cases (64%) of MPGN I without GBM disruption and 7 of 12 cases (58%) of MPGN IIIA/S with GBM disruption met the non-C3GN criteria with significant immunoglobulins' deposition. Regardless of the C3GN or non-C3GN diagnosis, the deposits in primary MPGN I and MPGN IIIA/S exhibited ill-defined, amorphous, and foggy characteristics similar to those found in postinfectious GN but were different from immune complex (IC) deposits seen in MPGN IIIB. Not only C3GN but also non-C3GN was due to mechanisms other than IC deposition as found in postinfectious GN. Consequently, GBM disruption of MPGN IIIA/S was not due to IC deposition.

Indexed as

GlomerulonephritisGlomerulonephritis, MembranoproliferativeComplement C3HumansMethenamineMicroscopy, ElectronPeriodic AcidRetrospective StudiesComplement C3MethenaminePeriodic AcidC3 glomerulonephritisC3 glomerulopathyElectron microscopyMembranoproliferative glomerulonephritis type IMembranoproliferative glomerulonephritis type III Anders and Strife subtypeMembranoproliferative glomerulonephritis type III Burkholder subtypePeriodic acid-methenamine silverRenal biopsy

Identifiers

PMID37823929
OpenAlexW4387563248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.