Evidence map›Paper›PMID 37823919›Full record

ArticleEJNMMI research2023

Myocardial glucose suppression may interfere with the detection of inflammatory cells with FDG-PET as suggested in a canine model of myocardial infarction.

Benjamin Wilk, Haris Smailovic, Rebecca Sullivan, Erik R Sistermans, John Butler, Hannah Jago, Michael Kovacs, Gerald Wisenberg, Jonathan D Thiessen, Frank S Prato

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Benjamin WilkDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada. bwilk@uwo.ca.ORCID http://orcid.org/0000-0002-2672-6817
Haris SmailovicDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada.
Rebecca SullivanDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada.
Erik R SistermansDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada.
John ButlerDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada.
Hannah JagoDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada.
Michael KovacsDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada.
Gerald WisenbergDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada.
Jonathan D ThiessenDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada.
Frank S PratoDepartment of Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, ON, N6A 4V2, Canada.ORCID http://orcid.org/0000-0002-4592-2522
Western University · CALawson Health Research Institute · CA

Funding

Canadian Foundation for Innovation 11358Natural Sciences and Engineering Research Council of Canada/Alliance ALLRP 557043-20Ontario Research Fund RE7-021
6 · The paper itself

Abstract

backgroundAfter myocardial infarction, fibrosis and an ongoing dysregulated inflammatory response have been shown to lead to adverse cardiac remodeling. FDG PET is an imaging modality sensitive to inflammation as long as suppression protocols are observed while gadolinium enhanced MRI can be used to determine extracellular volume (ECV), a measure of fibrosis. In patients, glucose suppression is achieved variously through a high fat diet, fasting and injection of heparin. To emulate this process in canines, a heparin injection and lipid infusion are used, leading to similar fatty acids in the blood. The aim of this study was to examine the effect of glucose suppression on the uptake of FDG in the infarcted myocardial tissue and also on the determination of ECV in both the infarcted tissue and in the myocardium remote to the zone of infarction during a long constant infusion of FDG and Gd-DTPA.

resultsExtracellular volume was affected neither by suppression nor the length of the constant infusion in remote and infarcted tissue. Metabolic rate of glucose in infarcted tissue decreased during and after suppression of glucose uptake by lipid infusion and heparin injection. An increase in fibrosis and inflammatory cells was found in the center of the infarct as compared to remote tissue.

conclusionThe decrease in the metabolic rate of glucose in the infarcted tissue suggests that inflammatory cells may be affected by glucose suppression through heparin injection and lipid infusion.

Indexed as

Canine modelGlucose suppressionMyocardial infarctionPET/MRI

Identifiers

PMID37823919
PMCPMC10570261
OpenAlexW4387563386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.