Evidence map›Paper›PMID 37823895›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

Exploring the anti-inflammatory potential of topical hyaluronic acid for vocal fold injury in a rat model.

David Hortobagyi, Tanja Grossmann, Andrijana Kirsch, Christina Winter, Eva Roblegg, Markus Gugatschka

Open access · hybridAbstract read
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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David Hortobagyi *Division of Phoniatrics, ENT University Hospital, Medical University of Graz, Auenbruggerplatz 26, 8036, Graz, Austria. david.hortobagyi@medunigraz.at.ORCID http://orcid.org/0000-0001-8132-0855
Tanja Grossmann *Division of Phoniatrics, ENT University Hospital, Medical University of Graz, Auenbruggerplatz 26, 8036, Graz, Austria.
Andrijana KirschDivision of Phoniatrics, ENT University Hospital, Medical University of Graz, Auenbruggerplatz 26, 8036, Graz, Austria.
Christina WinterInstitute of Pharmaceutical Sciences, Pharmaceutical Technology and Biopharmacy, University of Graz, Graz, Austria.
Eva RobleggInstitute of Pharmaceutical Sciences, Pharmaceutical Technology and Biopharmacy, University of Graz, Graz, Austria.
Markus GugatschkaDivision of Phoniatrics, ENT University Hospital, Medical University of Graz, Auenbruggerplatz 26, 8036, Graz, Austria.
Medical University of Graz · ATUniversity of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVocal fold injuries are associated with fibrosis and dysphonia, which is a major obstacle to surgical treatment. The aim of this study is to evaluate the effect of topical hyaluronic acid with or without diclofenac on the inflammatory phase of vocal fold wound healing.

methodsForty-one male Sprague-Dawley rats were randomly assigned to four groups: an uninjured control group, an injured control group without any treatment, and two intervention groups in which hyaluronic acid with or without diclofenac was applied to the injured vocal fold. Gene expression of inflammatory markers and ECM-related molecules were examined.

resultsVocal fold injury resulted in a significant upregulation of inflammatory parameters [Ptgs2, Il1b and Il10] and Has1. Tgfb1, Has3 and Eln gene expression were significantly downregulated by the topical application of hyaluronic acid. The combination of hyaluronic acid and diclofenac did not result in any significant changes.

conclusionsVocal fold wound healing was significantly improved by a single post-operative topical application of hyaluronic acid. The addition of diclofenac may provide no additional benefit.

Indexed as

Hyaluronic AcidVocal CordsAnimalsDiclofenacMaleRatsRats, Sprague-DawleyWound HealingDiclofenacHyaluronic AcidDiclofenacHyaluronic acidTopical treatmentVocal fold inflammationVocal fold injury

Identifiers

PMID37823895
PMCPMC10764393
OpenAlexW4387563330

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.