ArticleFood science & nutrition2023
Effects of isoflavone and probiotic intake on calcium transport and bone metabolism biomarkers in female rats.
Article in Food science & nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Stage-dependent effects of composite probiotics on gut mineral transport, Skeletal health, and egg quality in laying hens.Poultry science · 2026Article
- Current Concepts in Probiotic Safety and Efficacy.Nutrients · 2026Review
- Daidzein and Genistein: Natural Phytoestrogens with Potential Applications in Hormone Replacement Therapy.International journal of molecular sciences · 2025Review
- Anti-osteoporotic potential of a probiotic mixture containing Limosilactobacillus reuteri and Weissella cibaria in ovariectomized rats.Scientific reports · 2025Article
- Impact ofNutrients · 2024Article
- Effect of Tempeh and Daidzein on Calcium Status, Calcium Transporters, and Bone Metabolism Biomarkers in Ovariectomized Rats.Nutrients · 2024Article
- Effects of Daidzein, Tempeh, and a Probiotic Digested in an Artificial Gastrointestinal Tract on Calcium Deposition in Human Osteoblast-like Saos-2 Cells.International journal of molecular sciences · 2024Article
- Effects of daily probiotic supplementation withFrontiers in nutrition · 2024Article
- Influence of Isoflavones and Probiotics on Magnesium Status in Healthy Female Rats.Foods (Basel, Switzerland) · 2023Article
- Effects of isoflavone and probiotic intake on calcium transport and bone metabolism biomarkers in female rats.Food science & nutrition · 2023Article
- Association of probiotic ingestion with serum sex steroid hormones among pre- and postmenopausal women from the NHANES, 2013-2016.PloS one · 2023Observational
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium is essential for maintaining bone health as it contributes to bone formation, remodeling, strength, and density. This study investigated the effect of isoflavones and probiotics on calcium transporters' gene expression, serum calcium levels, and bone metabolism biomarkers in healthy female rats. Forty-eight female Wistar rats were classified into six groups. Bone metabolism biomarkers (pyridinoline, deoxypyridinoline, parathyroid hormone, and osteocalcin) and serum calcium levels were measured by enzyme-linked immunosorbent assay (ELISA) and atomic absorption spectroscopy (AAS), respectively. Gene expression of calcium transporters (Trpv5 and Trpv6) was evaluated in duodenum and jejunum tissue samples using quantitative polymerase chain reaction (qPCR). Trpv5 and Trpv6, epithelial calcium channels, play a crucial role in calcium transport and homeostasis in the body. The study consisted of a1-week adaptation period for the rats to adjust to the controlled conditions, followed by an 8-week intervention phase. The daidzein and genistein group showed a significant increase in the gene expression of the Trpv6 transporter in the duodenum and a marked decrease in serum pyridinoline levels compared to the control group. The tempeh and soybean groups showed a significant decrease in the gene expression of the Trpv5 calcium transporter in the jejunum. However, no significant influence of the
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