Evidence map›Paper›PMID 37823005›Full record

ArticleBiochemistry and biophysics reports2023

Activated protein C signaling mediates neuroinflammation in seizure induced by pilocarpine.

Linda Ines Zoungrana, Meredith Krause-Hauch, Hao Wang, Mohammad Kasim Fatmi, Zehui Li, Lily Slotabec, Adewale Segun James, Steven Didik, Ji Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Platelets at the intersection of inflammation and coagulation in the APC-mediated response to myocardial ischemia/reperfusion injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Linda Ines ZoungranaDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Meredith Krause-HauchDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Hao WangDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Mohammad Kasim FatmiDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Zehui LiDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Lily SlotabecDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Adewale Segun JamesDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Steven DidikDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Ji LiDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
University of South Florida · USJackson Memorial Hospital · US

Funding

The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI DAVID E STEC · 2023 to 2026
$6.3M
Metformin Therapy for Ischemic Insult and Reperfusion Injury in AgingR33AG071249 · NIA · VIRGINIA COMMONWEALTH UNIVERSITY · PI LESNEFSKY, EDWARD J, LI, JI · 2023 to 2024
$761k
Metformin Therapy for Ischemic Insult and Reperfusion Injury in AgingR21AG071249 · NIA · VIRGINIA COMMONWEALTH UNIVERSITY · PI LESNEFSKY, EDWARD J, LI, JI N, · 2021 to 2022
$433k
CSRD VA I01 CX002406NIA NIH HHS R21 AG071249NIA NIH HHS R33 AG071249NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P30 GM149404
6 · The paper itself

Abstract

Epilepsy is one of the most common and oldest neurological disorders, characterized by periodic seizures that affect millions globally. Despite its long history, its pathophysiology is not fully understood. Additionally, the current treatment methods have their limitations. Finding a new alternative is necessary. Activated Protein C (APC) has been proven to have neurological protection in other neurological disorders; however, there is no study that focuses on the role of APC in seizures. We propose that APC's protective effect could be associated with seizures through inflammation and apoptosis regulation. The results demonstrated that APC's pathway proteins are involved in neuroprotection mechanisms in seizure-induced models by acting on certain inflammatory factors, such as NF-κB and apoptosis proteins.

Indexed as

Activated protein CEpilepsyInflammation

Identifiers

PMID37823005
PMCPMC10562752
OpenAlexW4387190574

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.