Evidence map›Paper›PMID 37822765›Full record

ArticlePNAS nexus2023

Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils.

Miki Kato, Keisuke Maeda, Ryuichi Nakahara, Haruka Hirose, Ayano Kondo, Sho Aki, Maki Sugaya, Sana Hibino, Miyuki Nishida, Manami Hasegawa and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Miki KatoDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.ORCID https://orcid.org/0009-0002-5295-7405
Keisuke MaedaDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.
Ryuichi NakaharaDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.
Haruka HiroseDepartment of Systems Biology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japanxs.
Ayano KondoResearch Unit, R&D Division, Kyowa Kirin Co., Ltd., Tokyo 100-0004, Japan.
Sho AkiDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.
Maki SugayaDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.
Sana HibinoDepartment of Inflammology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.ORCID https://orcid.org/0000-0002-2296-0200
Miyuki NishidaDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.
Manami HasegawaDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.
Hinano MoritaCollege of Natural Sciences, University of Texas at Austin, Austion, TX 78712, USA.ORCID https://orcid.org/0009-0002-6806-3086
Ritsuko AndoDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.
Rika TsuchidaDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.
Minoru YoshidaChemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Saitama 351-0198, Japan.ORCID https://orcid.org/0000-0002-4376-5674
Tatsuhiko KodamaDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.
Hideyuki YanaiDepartment of Inflammology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.ORCID https://orcid.org/0000-0002-0115-9000
Teppei ShimamuraDepartment of Systems Biology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Tsuyoshi OsawaDivision of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo 153-8904, Japan.ORCID https://orcid.org/0000-0002-9479-6665
The University of Tokyo · JPTokyo Medical and Dental University · JPKyowa Kirin (Japan) · JPRIKEN Center for Sustainable Resource Science · JPThe University of Texas at Austin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An acidic tumor microenvironment plays a critical role in tumor progression. However, understanding of metabolic reprogramming of tumors in response to acidic extracellular pH has remained elusive. Using comprehensive metabolomic analyses, we demonstrated that acidic extracellular pH (pH 6.8) leads to the accumulation of N1-acetylspermidine, a protumor metabolite, through up-regulation of the expression of spermidine/spermine acetyltransferase 1 (

Indexed as

acidic extracellular pHcancer metabolismN1-acetylspermidineneutrophilsSAT1

Identifiers

PMID37822765
PMCPMC10563787
OpenAlexW4387495217

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.