ArticleFrontiers in endocrinology2023
Relationship between gut microbiota and thyroid function: a two-sample Mendelian randomization study.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Loss of microbial signals reprograms endocrine microenvironments and consistently reduces RESISTIN expression in the adrenal and thyroid cells of germ-free pigs.Genes & diseases · 2026Article
- Article
- Gut microbiota as key mediators of animal acclimation to temperature changes: mechanisms and interventions.Applied and environmental microbiology · 2026Review
- Metagenomic Analysis of Gut Microbiota Structure and Function in Adults with Subclinical Hypothyroidism: A Cross-Sectional Study in China.Microorganisms · 2025Article
- Lower Thyroid Function and Higher Plasma Choline: Effect Modification by Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2025Article
- Causal relationship between gut microbiota and dental caries: a two-sample mendelian randomization study.BDJ open · 2025Article
- Association between the newly proposed dietary index for gut microbiota and thyroid function: NHANES 2007-2012.Frontiers in nutrition · 2025Article
- Gut microbiota in hypothyroidism: pathogenic mechanisms and opportunities for precision microbiome interventions.Frontiers in microbiology · 2025Review
- Microbiota dysbiosis impact on the metabolism of T3 and T4 hormones and its association with thyroid cancer.Frontiers in cell and developmental biology · 2025Review
- The Role of Gluten in the Development of Autoimmune Thyroid Diseases: A Narrative Review.International journal of endocrinology and metabolism · 2024Review
- Association between gut microbiota and anxiety disorders: a bidirectional two-sample mendelian randomization study.BMC psychiatry · 2024Article
- Review
- Application of Mendelian randomization in thyroid diseases: a review.Frontiers in endocrinology · 2024Review
- Gut Microbiota Changes and Its Potential Relations with Thyroid Disorders: From Composition to Therapeutic Targets.International journal of general medicine · 2024Review
- Gut microbiota and autoimmune thyroid disease: a bidirectional Mendelian randomization study and mediation analysis.Frontiers in microbiology · 2024Article
- Mechanisms of microbiota-gut-brain axis communication in anxiety disorders.Frontiers in neuroscience · 2024Review
- Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis.Frontiers in microbiology · 2024Article
- Commentary: Causal effects of specific gut microbiota on bone mineral density: a two-sample Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Causal relationship between gut microbiota and thyroid nodules: a bidirectional two-sample Mendelian randomization study.Frontiers in endocrinology · 2024Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Numerous observational studies have indicated a link between the composition of gut microbiota and thyroid function. Nevertheless, the precise causal relationship between gut microbiota and thyroid function remains uncertain. Methods: In this two-sample Mendelian randomization study, we utilized summary data from a genome-wide association study of gut microbiota composition in 18,340 participants from 24 cohorts, as well as summary statistics on thyroid hormones and thyroid-stimulating hormone from the ThyroidOmics Consortium and summary statistics on hypothyroidism and hyperthyroidism from the FinnGen R8 release. Five different methods, including inverse variance weighting, MR-Egger, weighted median, weighted mode, and simple mode, were employed to examine the causal relationship between gut microbiota and thyroid function. Reverse Mendelian randomization analysis was conducted for taxa identified as having a causal relationship with thyroid function in the Mendelian randomization analysis. To assess the robustness of the results, sensitivity analyses were conducted employing Cochran's Q test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis. Results: Through MR analysis of 211 microbial taxa and 4 phenotypes, we identified a total of 34 gut microbiota taxa that were associated with the outcomes. After using the bonferroni method for multiple testing correction, phylum Conclusion: Through two-sample MR analysis, we identified specific gut microbiota taxa at the genetic level that are predicted to have a causal relationship with thyroid function, which may serve as useful biomarkers for early disease diagnosis.
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