Evidence map›Paper›PMID 37822516›Full record

ArticleIBRO neuroscience reports2023

Non-canonical C-terminal variant of MeCP2 R344W exhibits enhanced degradation rate.

Yue Chai, Sharon Shui Ying Lee, Amelle Shillington, Xiaoli Du, Catalina Ka Man Fok, Kam Chun Yeung, Gavin Ka Yu Siu, Shiyang Yuan, Zhongyu Zheng, Hayley Wing Sum Tsang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Yue ChaiSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Sharon Shui Ying LeeSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Amelle ShillingtonDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Xiaoli DuDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Catalina Ka Man FokSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Kam Chun YeungSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Gavin Ka Yu SiuSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Shiyang YuanSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Zhongyu ZhengSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Hayley Wing Sum TsangDivision of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong, China.
Shen GuSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Yu ChenChinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Tao YeChinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Jacque Pak Kan IpSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Chinese University of Hong Kong · HKChinese Academy of Sciences · CNCincinnati Children's Hospital Medical Center · USHong Kong University of Science and Technology · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rett Syndrome (RTT) is a neurodevelopmental disorder caused by pathogenic variants in the

Indexed as

Carboxyl-terminal domain (C-terminal domain)Methyl-CpG binding domain 2 (MECP2)Missense variantProtein degradationProtein stabilityR344WRett Syndrome

Identifiers

PMID37822516
PMCPMC10562907
OpenAlexW4386954489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.