Evidence map›Paper›PMID 37822511›Full record

ArticleiScience2023

Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population.

Hui Xue, Xiaojun Xu, Zhihan Yan, Jingliang Cheng, Longjiang Zhang, Wenzhen Zhu, Guangbin Cui, Quan Zhang, Shijun Qiu, Zhenwei Yao and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 19 institutions in 1 country.

Hui XueDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
Xiaojun XuDepartment of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China.
Zhihan YanDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Jingliang ChengDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Longjiang ZhangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China.
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Guangbin CuiFunctional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.
Quan ZhangDepartment of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China.
Shijun QiuDepartment of Medical Imaging, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China.
Zhenwei YaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Wen QinDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
Feng LiuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
Meng LiangSchool of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin 300203, China.
Jilian FuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
Qiang XuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
Jiayuan XuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
Yingying XieDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
Peng ZhangDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Wei LiDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Caihong WangDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Wen ShenDepartment of Radiology, Tianjin First Center Hospital, Tianjin 300192, China.
Xiaochu ZhangDivision of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China.
Kai XuDepartment of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China.
Xi-Nian ZuoDevelopmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Zhaoxiang YeDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Yongqiang YuDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Junfang XianDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Chunshui YuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
CHIMGEN Consortium
Tianjin Medical University General Hospital · CNTianjin Medical University Cancer Institute and Hospital · CNFirst Affiliated Hospital of Zhengzhou University · CNAir Force Medical University · CNAnhui Medical University · CNBeijing Normal University · CNBeijing Tongren Hospital · CNChinese Academy of Sciences · CNChinese People's Armed Police General Hospital · CNFirst Affiliated Hospital of Guangzhou University of Chinese Medicine · CNFudan University · CNNanjing General Hospital of Nanjing Military Command · CNSecond Affiliated Hospital of Zhejiang University · CNTianjin First Center Hospital · CNTianjin Medical University · CNTongji Hospital · CNUniversity of Science and Technology of China · CNWenzhou Medical University · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Correlation between blood-oxygen-level-dependent (BOLD) and cerebral blood flow (CBF) has been used as an index of neurovascular coupling. Hippocampal BOLD-CBF correlation is associated with neurocognition, and the reduced correlation is associated with neuropsychiatric disorders. We conducted the first genome-wide association study of the hippocampal BOLD-CBF correlation in 4,832 Chinese Han subjects. The hippocampal BOLD-CBF correlation had an estimated heritability of 16.2-23.9% and showed reliable genome-wide significant association with a locus at 3q28, in which many variants have been linked to neuroimaging and cerebrospinal fluid markers of Alzheimer's disease. Gene-based association analyses showed four significant genes (

Indexed as

Association analysisGenomicsMedical imagingNeuroanatomyNeurogenetics

Identifiers

PMID37822511
PMCPMC10562876
OpenAlexW4386913779

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.