ArticleiScience2023
Natural brain state change with E/I balance shifting toward inhibition is associated with vigilance impairment.
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Concurrent Multimodal Imaging Demonstrates That EEG-Based Excitation/Inhibition Balance Reflects Glutamate and GABA Balance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- VGLUT1 and PSD-95 Expression Remains Stable in the Prefrontal and Cerebellar Cortices of the VPA Autism Rat Model.Developmental neurobiology · 2026Article
- Forward programming of human pluripotent stem cells to generate glutamatergic and GABAergic neurons in a tri-culture model with astrocytes.Stem cell research & therapy · 2026Article
- Genetic contributions to brain criticality and its relationship with human cognitive functions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome.Biology · 2025Review
- Age predicts peak gamma frequency and N1 amplitude of visual evoked potential.BMC neuroscience · 2025Article
- The level of cognitive functioning in school-aged children is predicted by resting EEG Directed Phase Lag Index.Scientific reports · 2025Article
- The effects of amyloidosis and aging on glutamatergic and GABAergic synapses, and interneurons in the barrel cortex and non-neocortical brain regions.Frontiers in neuroanatomy · 2025Article
- Genomic, molecular, and cellular divergence of the human brain.Trends in neurosciences · 2024Review
- Excitation/Inhibition balance relates to cognitive function and gene expression in temporal lobe epilepsy: a high density EEG assessment with aperiodic exponent.Brain communications · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The delicate balance between cortical excitation and inhibition (E/I) plays a pivotal role in brain state changes. While previous studies have associated cortical hyperexcitability with brain state changes induced by sleep deprivation, whether cortical hypoexcitability is also linked to brain state changes and, if so, how it could affect cognitive performance remain unknown. Here, we address these questions by examining the brain state change occurring after meals, i.e., postprandial somnolence, and comparing it with that induced by sleep deprivation. By analyzing features representing network excitability based on electroencephalogram (EEG) signals, we confirmed cortical hyperexcitability under sleep deprivation but revealed hypoexcitability under postprandial somnolence. In addition, we found that both sleep deprivation and postprandial somnolence adversely affected the level of vigilance. These results indicate that cortical E/I balance toward inhibition is associated with brain state changes, and deviation from the balanced state, regardless of its direction, could impair cognitive performance.
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