Evidence map›Paper›PMID 37822447›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2023

The Relevance of Advanced Therapy Medicinal Products in the Field of Transplantation and the Need for Academic Research Access: Overcoming Bottlenecks and Claiming a New Time.

Lorenzo Piemonti, Hanne Scholz, Dide de Jongh, Julie Kerr-Conte, Aart van Apeldoorn, James A M Shaw, Marten A Engelse, Eline Bunnik, Markus Mühlemann, Karolina Pal-Kutas and 4 more

Abstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. 3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  6. Review
  7. The Last Mile in Beta-Cell Replacement Therapy for Type 1 Diabetes: Time to Grow Up.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  8. Allogeneic Islet Transplantation: Chronicle of a Death Foretold?Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  9. Article
  10. Review
  11. ESOT Roadmap for Advanced Therapy Medicinal Products in Transplantation: Navigating Regulatory Challenges to Enhance Access and Care.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  12. Article
  13. Cautious Optimism Warranted for Stem Cell-Derived Islet Transplantation in Type 2 Diabetes.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lorenzo PiemontiDiabetes Research Institute, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.
Hanne ScholzDepartment of Transplant Medicine and Institute for Surgical Research, Oslo University Hospital, Oslo, Norway.
Dide de JonghDepartment of Medical Ethics, Philosophy and History of Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands.
Julie Kerr-ConteUniversité de Lille, INSERM, Campus Hospitalo-Universitaire de Lille, Institut Pasteur de Lille, U1190-EGID, Lille, France.
Aart van ApeldoornDepartment CBITE, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, Netherlands.
James A M ShawTranslational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.
Marten A EngelseNephrology, Leiden University Medical Center, Leiden, Netherlands.
Eline BunnikDepartment of Medical Ethics, Philosophy and History of Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands.
Markus MühlemannKugelmeiers Ltd., Zollikerberg, Switzerland.
Karolina Pal-KutasKugelmeiers Ltd., Zollikerberg, Switzerland.
William E ScottTranslational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.
Jérémy MagalonLaboratoire de Culture et Thérapie Cellulaire, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
Patrick Kugelmeier *Kugelmeiers Ltd., Zollikerberg, Switzerland.
Ekaterine Berishvili *Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The field of transplantation has witnessed the emergence of Advanced Therapy Medicinal Products (ATMPs) as highly promising solutions to address the challenges associated with organ and tissue transplantation. ATMPs encompass gene therapy, cell therapy, and tissue-engineered products, hold immense potential for breakthroughs in overcoming the obstacles of rejection and the limited availability of donor organs. However, the development and academic research access to ATMPs face significant bottlenecks that hinder progress. This opinion paper emphasizes the importance of addressing bottlenecks in the development and academic research access to ATMPs by implementing several key strategies. These include the establishment of streamlined regulatory processes, securing increased funding for ATMP research, fostering collaborations and partnerships, setting up centralized ATMP facilities, and actively engaging with patient groups. Advocacy at the policy level is essential to provide support for the development and accessibility of ATMPs, thereby driving advancements in transplantation and enhancing patient outcomes. By adopting these strategies, the field of transplantation can pave the way for the introduction of innovative and efficacious ATMP therapies, while simultaneously fostering a nurturing environment for academic research.

Indexed as

Cell- and Tissue-Based TherapyTissue EngineeringGenetic TherapyHumansadvanced therapy medicinal products (ATMPs)clinical trialsrare diseasesregulatory processestransplantation

Identifiers

PMID37822447
PMCPMC10563816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.