Evidence map›Paper›PMID 37822359›Full record

ArticleFrontiers in cellular and infection microbiology2023

Airway epithelial cells mount an early response to mycobacterial infection.

Amy M Barclay, Dennis K Ninaber, Suzanne van Veen, Pieter S Hiemstra, Tom H M Ottenhoff, Anne M van der Does, Simone A Joosten

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Immunodominant Tuberculosis Antigens Recognized by Human CD4Cold Spring Harbor perspectives in medicine · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Frontiers in microbiology · 2026
    Article
  9. Article
  10. Article
  11. An alveolus lung-on-a-chip model ofbioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Experimental dissection of tuberculosis protective immunity: a human perspective.Frontiers in cellular and infection microbiology · 2025
    Review
  15. Article
  16. Review
  17. Characterizing the immune response toFrontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amy M BarclayDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Dennis K NinaberDepartment of Pulmonology, Leiden University Medical Center, Leiden, Netherlands.
Suzanne van VeenDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Pieter S HiemstraDepartment of Pulmonology, Leiden University Medical Center, Leiden, Netherlands.
Tom H M OttenhoffDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Anne M van der DoesDepartment of Pulmonology, Leiden University Medical Center, Leiden, Netherlands.
Simone A JoostenDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung epithelial cells represent the first line of host defence against foreign inhaled components, including respiratory pathogens. Their responses to these exposures may direct subsequent immune activation to these pathogens. The epithelial response to mycobacterial infections is not well characterized and may provide clues to why some mycobacterial infections are cleared, while others are persistent and pathogenic. We have utilized an air-liquid interface model of human primary bronchial epithelial cells (ALI-PBEC) to investigate the epithelial response to infection with a variety of mycobacteria:

Indexed as

Mycobacterium InfectionsMycobacterium tuberculosisChemokinesCytokinesEpithelial CellsHumansChemokinesCytokinesair-liquid interface (ALI) 3D in vitro modelairway epitheliumhost-pathogen interactionnon-tuberculous mycobacteriatuberculosis

Identifiers

PMID37822359
PMCPMC10562574
OpenAlexW4387103537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.