ArticleAnnals of clinical and translational neurology2023
Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes.
Article in Annals of clinical and translational neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- A systematic review and coordinate-based meta-analysis of resting-state fMRI in athletes from open and closed skills sports.Scientific reports · 2025Pooled it
- A systematic review of the impact of type 2 diabetes on brain cortical thickness.Frontiers in dementia · 2024Pooled it
- Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes.Nutrition & diabetes · 2025Trial
- Measures of Brain Metabolism and Diffusion in Neonates of Mothers with Diabetes.AJNR. American journal of neuroradiology · 2026Article
- Temporal dynamic of cognitive decline in type 2 diabetes mellitus patients: a multimodal biomarker analysis using event-based modal and principal component analysis.Diabetology & metabolic syndrome · 2025Article
- Characterization of changes in the resting-state intrinsic network in patients with diabetic peripheral neuropathy.Scientific reports · 2024Article
- Aberrant Brain Triple-Network Effective Connectivity Patterns in Type 2 Diabetes Mellitus.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Altered Density of Resting-State Long- and Short-Range Functional Connectivity in Patients with Moderate-to-Severe Obstructive Sleep Apnea.Nature and science of sleep · 2024Article
- Association of individual-based morphological brain network alterations with cognitive impairment in type 2 diabetes mellitus.Frontiers in neurology · 2024Article
- Potential effects of peripheral neuropathy on brain function in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- Aberrant Modular Segregation of Brain Networks in Patients with Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- White matter differences in motor and affective-motivational networks of pain-indifferent carriers of the R221W mutation.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveWe aimed to reveal the role of structural and functional alterations of cingulate gyrus in early cognitive impairment in Type 2 diabetes mellitus (T2DM) patients.
methodsFifty-six T2DM patients and 60 healthy controls (HCs) underwent a neuropsychological assessment and sagittal three-dimensional T1-weighted and resting-state functional MRI. Differences in the cortical thickness of the cingulate cortex and the functional connectivity (FC) of the nine subregions of the cingulate gyrus and the whole brain were compared between T2DM patients and HCs. Correlation analysis was performed between cortex thickness and FC and the participants' clinical/cognitive variables.
resultsThe cortical thickness of the cingulate gyrus was not significantly different between T2DM patients and HCs. However, the T2DM patients showed significantly lower FC between the pregenual ACC (pACC) and the bilateral hippocampus, significantly higher FC between the pACC and bilateral lateral prefrontal cortex (LPFC) and left precentral gyrus, and significantly lower FC between the retrosplenial cortex (RSC) and right cerebellar Crus I. The FC between the pACC and the left hippocampus was negatively correlated with the FC between the pACC and LPFC (r = -0.306, p = 0.022).
interpretationThe pACC and the RSC show dysfunctional connectivity before the appearance of structural abnormalities in T2DM patients. Abnormal FC of the pACC with the bilateral hippocampus and LPFC may imply a neural compensatory mechanism for memory function. These findings provide valuable information and new directions for possible interventions for the T2DM-related cognitive impairment.
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