ArticlePlant biotechnology journal2024
Specific members of the TOPLESS family are susceptibility genes for Fusarium wilt in tomato and Arabidopsis.
Article in Plant biotechnology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- The Conserved Guanyl-Specific Ribonuclease T1 Effector EC19 Is Required for Full Virulence of the Vascular Wilt Fungus Fusarium oxysporum on Tomato.Molecular plant pathology · 2026Article
- The Fungal Pathogen Fusarium graminearum Can Hydrolyse Tryptamine-Derived Hydroxy-Cinnamic Acid Amide Defence Compounds, and Generates Highly Increased Auxin Levels in Wheat via Copper Amine-Oxidases.Molecular plant pathology · 2026Article
- CONSERVATION AND DIVERGENCE WITHIN THEbioRxiv : the preprint server for biology · 2026Article
- Solanaceous vegetables andHorticulture research · 2026Article
- The Effector SIX8 Contributes to Virulence of Fusarium oxysporum f. sp. lactucae Race 4 on Lettuce.Molecular plant pathology · 2026Article
- Accelerating Resistance Breeding: Emerging Methods to Identify and Validate Plant Immunity Genes.Plants (Basel, Switzerland) · 2026Review
- Molecular Strategies and Regulatory Networks in the Early Infection Stages of Plant Pathogenic Fusarium Species.The plant pathology journal · 2026Review
- Navigating Fusarium wilt of bananas: a ready-to-use subset of resistantFrontiers in plant science · 2026Review
- Identification of candidate genes involved in root gall formation during early infection ofFrontiers in plant science · 2026Article
- Turning Susceptibility into Strength: A New Era of Durable Resistance in Plants Through Genome Editing.Plants (Basel, Switzerland) · 2025Review
- Divergent ECC1 effector homologs modulate host-specific virulence in cucurbit-infectingFrontiers in cellular and infection microbiology · 2025Article
- TomatoFrontiers in plant science · 2024Article
- Comparative genomics and transcriptomics reveal differences in effector complement and expression between races ofFrontiers in plant science · 2024Article
- The TPX family of co-repressors: a hub amidst the hubbub.Physiologia plantarumReview
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Vascular wilt diseases caused by Fusarium oxysporum are a major threat to many agriculturally important crops. Genetic resistance is rare and inevitably overcome by the emergence of new races. To identify potentially durable and non-race-specific genetic resistance against Fusarium wilt diseases, we set out to identify effector targets in tomato that mediate susceptibility to the fungus. For this purpose, we used the SIX8 effector protein, an important and conserved virulence factor present in many pathogenic F. oxysporum isolates. Using protein pull-downs and yeast two-hybrid assays, SIX8 was found to interact specifically with two members of the tomato TOPLESS family: TPL1 and TPL2. Loss-of-function mutations in TPL1 strongly reduced disease susceptibility to Fusarium wilt and a tpl1;tpl2 double mutant exerted an even higher level of resistance. Similarly, Arabidopsis tpl;tpr1 mutants became significantly less diseased upon F. oxysporum inoculation as compared to wildtype plants. We conclude that TPLs encode susceptibility genes whose mutation can confer resistance to F. oxysporum.
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