Evidence map›Paper›PMID 37821973›Full record

ArticleAlzheimer's research & therapy2023

Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?

Clément Aveneau, David Wallon, Bertrand Degos, Alexandre Obadia, Claire Hourregue, Sarah Benisty, Béatrice Garcin, Julien Dumurgier, Claire Paquet

Abstract readMulticenter Study
In one paragraph

Article in Alzheimer's research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Clément AveneauCognitive Neurology Center, Université Paris Cité, Lariboisière Fernand Widal Hospital, Assistance PubliqueHôpitaux de Paris, Paris, France.
David WallonDepartment of Neurology and CNR-MAJ, 76000INSERM U1245, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, CHU Rouen, Rouen, France.
Bertrand DegosNeurology Department, Avicenne Hospital, APHP, Hôpitaux, Universitaires de Paris-Seine Saint Denis (HUPSSD), Sorbonne Paris Nord, Réseau NS-PARK/FCRIN, Bobigny, France.
Alexandre ObadiaNeurology Department, Fondation Adolphe de Rothschild, Paris, France.
Claire HourregueCognitive Neurology Center, Université Paris Cité, Lariboisière Fernand Widal Hospital, Assistance PubliqueHôpitaux de Paris, Paris, France.
Sarah BenistyNeurology Department, Fondation Adolphe de Rothschild, Paris, France.
Béatrice GarcinNeurology Department, Avicenne Hospital, APHP, Hôpitaux, Universitaires de Paris-Seine Saint Denis (HUPSSD), Sorbonne Paris Nord, Réseau NS-PARK/FCRIN, Bobigny, France.
Julien DumurgierCognitive Neurology Center, Université Paris Cité, Lariboisière Fernand Widal Hospital, Assistance PubliqueHôpitaux de Paris, Paris, France.
Claire PaquetCognitive Neurology Center, Université Paris Cité, Lariboisière Fernand Widal Hospital, Assistance PubliqueHôpitaux de Paris, Paris, France. claire.paquet@inserm.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe first predominant clinical symptoms of dementia with Lewy bodies (DLB) are highly variable; however, the prognosis based on initial predominant symptoms remains poorly understood.

methodsMulticenter retrospective study in 4 French expert neurological centers. Patients were categorized in 3 groups according to their first more predominant symptoms: cognitive, psychiatric, or motor.

resultsAnalysis of 310 DLB patients. The mean age was 73.5 years old (SD 7.5) including 32.3% of women. The mean follow-up was 7.25 years (SD 3.6). We observed that the full clinical picture was more frequent in the motor group than in the cognitive group (p = 0.01); male gender and age at onset were associated with a significant excess risk of instantaneous mortality (p = 0.01).

conclusionInitial symptoms may affect the clinical course of patients, but no significant difference in mortality was observed.

Indexed as

Lewy Body DiseaseAgedAge of OnsetFemaleHumansMalePrognosisRetrospective StudiesClinical subtypesDementia with Lewy bodyOnsetProdromalPrognosis

Identifiers

PMID37821973
PMCPMC10565988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.