ArticleBMC public health2023
Prospective study of the association between chronotype and cardiometabolic risk among Chinese young adults.
Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Evening Chronotype Is Associated With Daytime Impairment and Differential Sleep and Circadian Response to a Sleep Extension Manipulation in Short Sleeping Adolescents.Journal of sleep research · 2026Trial
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- A newly developed circadian imbalance index (CII) and risk of cardiovascular-kidney-metabolic disease in the UK biobank.European journal of epidemiology · 2026Article
- Latent Profiles of Psychological Distress and Suicidal Ideation Among Nursing Students: A Cross-Sectional Study of Associated Factors.Depression and anxiety · 2026Article
- Modifying effects of compensatory sleep on elevated blood pressure related to school-day sleep patterns.BMC medicine · 2025Article
- Prevalence of dry eye disease and its association with sleep quality and depression: a hospital-based survey in Thai population.BMJ open · 2025Article
- Evaluation of Cardiovascular Disease Risk According to the Morningness-Eveningness Status in Adult Individuals.Cureus · 2025Article
- Association of Chronotype with Hypertension and Metabolic Parameters in Middle-Aged and Older Adults: A Cross-Sectional Study.Nature and science of sleep · 2025Article
- Impact of sleep chronotype on blood pressure and metabolic markers.Frontiers in neurology · 2025Article
- Circadian rhythm and aggressive behavior in community-dwelling schizophrenia patients testing a moderated mediation model.Frontiers in psychiatry · 2025Article
- Chrononutrition behaviors and cardiometabolic risk in adolescence: an ecological momentary assessment study.European journal of nutrition · 2024Article
- Weight-neutral approach and later sleep midpoint in adolescents with "emerging polycystic ovary syndrome phenotype" as vehicles for sustainable weight loss.F&S reports · 2024Article
- Exercise systolic blood pressures are unaffected by time of day in healthy young adults.Journal of human hypertension · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association of evening chronotype with cardiometabolic disease has been well established. However, the extent to which circadian rhythm disturbances independently result in risk remains unclear. This study aimed to investigate the cross-sectional and prospective longitudinal associations between chronotype and cardiometabolic risk among Chinese young adults.
methodsFrom April to May 2019, a total of 1 135 young adults were selected to complete the self-administered questionnaire, and 744 fasting blood samples were collected to quantify cardiometabolic parameters. From April to May 2021, 340 fasting blood samples were collected to quantify cardiometabolic parameters. The Morning and Evening Questionnaire 5 (MEQ-5) was used to assess chronotype. The cardiometabolic (CM)-risk score was the sum of standardized Z scores based on gender for the 5 indicators: waist circumference (WC), mean arterial pressure (MAP), triglyceride (TG), homeostasis model assessment for insulin resistance (HOMA-IR), and high-density lipoprotein cholesterol (HDL-C), where the HDL-C is multiplied by-1. The generalized linear model was used to determine the cross-sectional and prospective longitudinal associations between chronotype and each cardiometabolic parameter.
resultsCross-sectional association analysis showed that lower MEQ-5 scores were correlated with higher fasting insulin (β=-1.420, 95%CI: -2.386~-0.453), higher HOMA-IR (β=-0.301, 95%CI: -0.507~-0.095), and higher CM risk score (β=-0.063, 95%CI: -0.122~-0.003), even after adjustment for covariates. Prospective longitudinal association analysis also showed that lower MEQ-5 scores were associated with 2 years later higher fasting glucose (β=-0.018, 95%CI: -0.034~-0.003), higher fasting insulin (β=-0.384, 95%CI: -0.766~-0.003), higher HOMA-IR (β=-0.089, 95%CI: -0.176~-0.002), and higher CM-risk score (β=-0.109, 95%CI: -0.214~-0.003) after adjustment for covariates.
conclusionsEvening chronotype was significantly correlated with higher CM risk among young adults. Our findings suggest that biologically and socially affected sleep timing misalignment is a contributing factor to cardiovascular disease risk.
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