Evidence map›Paper›PMID 37821793›Full record

ArticlePharmacological reports : PR2023

Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation.

Jarogniew J Łuszczki, Hubert Bojar, Katarzyna Jankiewicz, Magdalena Florek-Łuszczki, Jarosław Chmielewski, Krystyna Skalicka-Woźniak

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological reports : PR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Protective Effects and Mechanism ofInternational journal of molecular sciences · 2024
    Article
  3. Quantitative Analysis of Isopimpinellin fromMolecules (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jarogniew J ŁuszczkiDepartment of Occupational Medicine, Medical University of Lublin, 20-090, Lublin, Poland. jarogniew.luszczki@umlub.pl.ORCID http://orcid.org/0000-0002-3059-0393
Hubert BojarDepartment of Toxicology and Food Safety, Institute of Rural Health, 20-950, Lublin, Poland.ORCID http://orcid.org/0000-0003-4887-7541
Katarzyna Jankiewicz2nd Department of Gynecology, Medical University of Lublin, 20-954, Lublin, Poland.ORCID http://orcid.org/0000-0001-5453-4460
Magdalena Florek-ŁuszczkiDepartment of Anthropology, Institute of Rural Health, 20-950, Lublin, Poland.ORCID http://orcid.org/0000-0003-1489-2399
Jarosław ChmielewskiInstitute of Environmental Protection, National Research Institute, 02-170, Warsaw, Poland.ORCID http://orcid.org/0000-0003-2606-1656
Krystyna Skalicka-WoźniakDepartment of Natural Products Chemistry, Medical University of Lublin, 20-093, Lublin, Poland.ORCID http://orcid.org/0000-0002-9313-5929
Medical University of Lublin · PLInstytut Medycyny Wsi im. Witolda Chodźki · PLInstitute of Environmental Protection · PL

Funding

Narodowe Centrum Nauki 2017/27/B/NZ4/00917
6 · The paper itself

Abstract

backgroundOverwhelming evidence indicates that some naturally occurring coumarins and terpenes are widely used in folk medicine due to their various therapeutic effects affecting the brain. Antiseizure medications (ASMs) are the principal treatment option for epilepsy patients, although some novel strategies based on naturally occurring substances are intensively investigated. This study was aimed at determining the influence of isopimpinellin (ISOP-a coumarin) when administered either separately or in combination with borneol (BOR-a monoterpenoid), on the antiseizure potencies of four classic ASMs (carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), and valproate (VPA)) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures. MATERIALS: Tonic-clonic seizures were evoked experimentally in mice after systemic (ip) administration of the respective doses of ISOP, BOR, and classic ASMs. Interactions for two-drug (ISOP + a classic ASM) and three-drug (ISOP + BOR + a classic ASM) mixtures were assessed isobolographically in the mouse MES model.

resultsISOP (administered alone) had no impact on the anticonvulsant potencies of four classic ASMs. Due to the isobolographic transformation of data, the combination of ISOP + VPA exerted an antagonistic interaction, whereas the two-drug mixtures of ISOP + CBZ, ISOP + PHT, and ISOP + PB produced additive interactions in the mouse MES model. The three-drug combinations of ISOP + BOR with CBZ and PHT produced additive interactions, while the three-drug combinations of ISOP + BOR with PB and VPA exerted synergistic interactions in the mouse MES model.

conclusionsThe most intriguing interaction was that for ISOP + VPA, for which the addition of BOR evoked a transition from antagonism to synergy in the mouse MES model.

Indexed as

AnticonvulsantsSeizuresAnimalsCamphanesCarbamazepineDisease Models, AnimalDose-Response Relationship, DrugDrug CombinationsDrug InteractionsElectroshockFurocoumarinsHumansMicePhenobarbitalPhenytoinAnticonvulsantsCamphanesCarbamazepineDrug CombinationsFurocoumarinsisoborneolisopimpinellinPhenobarbitalPhenytoinAntiseizure medicationBorneolCoumarinIsobolographic transformationIsopimpinellinMaximal electroshock

Identifiers

PMID37821793
PMCPMC10661746
OpenAlexW4387522470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.