ArticleNature2023
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 425 papers.
0numbers the graph read from it
0cells of the map it votes in
425citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
425 citing papers in PubMed.
- Exploratory Effects of a Novel Nutraceutical on Senescence-Related Protein Biomarkers in Healthy Adults: A Pilot Proteomics Study.International journal of molecular sciences · 2026Trial
- Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a phase II trial.Nature communications · 2026Trial
- Remodeling of innate antiviral immunity in aging.Cell insight · 2026Review
- A BAI1-PSTB-Hydrogel promotes diabetic wound healing by targeting mtDNA leakage and the cGAS-STING axis to alleviate endothelial senescence.Bioactive materials · 2026Article
- Genomic, epigenomic and transcriptomic regulation of cellular senescence.Nature reviews. Genetics · 2026Review
- A nucleic acid regulation strategy under mechanical stress for intervertebral disc degeneration treatment.Bioactive materials · 2026Article
- Polymer-Zn(II) sunscreens for protection against harmful blue ray.Bioactive materials · 2026Article
- Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Mitochondrial dysfunction and inflammaging: a mechanistic bridge between bioenergetic failure and senescence.GeroScience · 2026Review
- Mechanistic reprogramming of the mtDNA-cGAS-STING axis in cellular senescence: from mitochondrial homeostatic disruption to inflammatory and immune outcomes.Biogerontology · 2026Review
- The cGAS-STING/MITA pathway in innate antiviral immunity and beyond.Cell insight · 2026Review
- High-Fat Diet-Induced Metabolic Stress Durably Reprograms the Liver Regenerative Compartment Toward a Senescence-Like State.Aging cell · 2026Article
- Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial.Nature metabolism · 2026Article
- Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications.Journal of hematology & oncology · 2026Review
- Role of HSP72 in alleviating heat stress-induced damage in Sertoli cells of dairy bulls.Histochemistry and cell biology · 2026Article
- Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A mitoxyperiosis-associated gene signature correlates with immune disturbance and provides a potential diagnostic biomarker for systemic lupus erythematosus.Clinical rheumatology · 2026Article
- Ubiquitination-mediated degradation of NLRX1 drives metabolic vulnerability and accelerates intervertebral disc degeneration.Cell death and differentiation · 2026Article
- Peroxisomal Import Stress Drives Cellular Senescence through SCAF1-dependent Suppression of Mitoribosome Biogenesis.bioRxiv : the preprint server for biology · 2026Article
- The role of senescence in kidney ageing, injury and fibrosis.Nature reviews. Nephrology · 2026Review
365 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
39 authors.
Stella Victorelli *Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5573-8019
Hanna Salmonowicz *Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
James Chapman *Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-2841-282X
Helene MartiniDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Maria Grazia VizioliDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Joel S RileyCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0001-9170-5716
Catherine CloixCancer Research UK Scotland Institute, Glasgow, UK.
Ella Hall-YoungerCancer Research UK Scotland Institute, Glasgow, UK.
Jair Machado Espindola-NettoRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Diana JurkDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-4486-0857
Anthony B LagnadoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Lilian Sales GomezDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5309-7438
Joshua N FarrDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-3179-6414
Dominik SaulRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-0673-3710
Rebecca ReedBiosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.
George KellyBiosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.
Madeline EppardDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Laura C GreavesWellcome Centre for Mitochondrial Research, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Zhixun DouCenter for Regenerative Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-3069-3907
Nicholas PiriusDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Karolina SzczepanowskaReMedy International Research Agenda Unit, IMol Polish Academy of Sciences, Warsaw, Poland.
Rebecca A PorrittSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-0973-5092
Huijie HuangDegenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Timothy Y HuangDegenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Derek A MannNewcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0003-0950-243X
Claudio Akio MasudaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Sundeep KhoslaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-2936-4372
Haiming DaiDivision of Oncology Research and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-0484-7407
Scott H KaufmannDivision of Oncology Research and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4900-7145
Emmanouil ZacharioudakisDepartment of Biochemistry, Department of Medicine, Montefiore Einstein Cancer Center, Wilf Family Cardiovascular Research Institute, Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.
Evripidis GavathiotisDepartment of Biochemistry, Department of Medicine, Montefiore Einstein Cancer Center, Wilf Family Cardiovascular Research Institute, Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-6319-8331
Nathan K LeBrasseurRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-2002-0418
Xue LeiCancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Alva G SainzSalk Institute for Biological Studies, La Jolla, CA, USA.
Viktor I KorolchukBiosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.
Peter D AdamsCancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-0684-1770
Gerald S ShadelSalk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0003-2899-8717
Stephen W G TaitCancer Research UK Scotland Institute, Glasgow, UK. Stephen.Tait@glasgow.ac.uk.ORCID 0000-0001-7697-132X
João F PassosDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. passos.joao@mayo.edu.ORCID 0000-0001-8765-1890
Funding
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Diana Jurk · 2019 to 2026
$28.7MProject 4: Interrogating and harnessing age-related IFN signaling and innate immunity in HCC prevention and therapyP01AG073084 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PETER D. ADAMS, GERALD SHADEL · 2021 to 2026
$13.6MMidwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5MTranslational Geroscience NetworkR33AG061456 · NIA · MAYO CLINIC ROCHESTER · PI JAMES L. KIRKLAND, STEPHEN B. KRITCHEVSKY · 2019 to 2026
$6.2MSan Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0MNovel roles for the Alzheimer's Disease (AD) risk gene, SORLA in neuroprotection in ADR01AG061875 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI HUANG, TIMOTHY YIKAI · 2018 to 2022
$3.4MElucidating a microgliaassociated role for SORLA in modulating AD pathogenesisRF1AG070391 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI HUANG, TIMOTHY YIKAI · 2022 to 2022
$2.8MSenescent cells drive mt-DNA accumulation and inflamm-agingR01AG064165 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI TULLIUS, STEFAN GUNTHER · 2020 to 2024
$2.6MDefining the interactions of senescent immune cells and skeletal cellsR01AG076515 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, David G Monroe · 2022 to 2026
$2.4MCytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventionsR01AG071861 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ADAMS, PETER D. · 2021 to 2025
$2.3MThe role of sub-lethal mitochondrial apoptotic stress in cellular senescenceR01AG068048 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2020 to 2024
$2.2MMitochondrial DNA Stress Activation of Interferon Signaling and Lupus PathologyR01AR069876 · NIAMS · YALE UNIVERSITY · PI SHADEL, GERALD · 2017 to 2021
$2.1MCancer Research UK 23390Cancer Research UK DRCPFA-NOV22/100001Cancer Research UK DRCRPG-NOV22/100007Medical Research Council MR/L016354/1Medical Research Council MR/R023026/1NCI NIH HHS R01 CA225996NCI NIH HHS UG3 CA268103NCI NIH HHS UH3 CA268103NIAMS NIH HHS R01 AR069876NIA NIH HHS F31 AG062099NIA NIH HHS P01 AG062413NIA NIH HHS P01 AG073084NIA NIH HHS P30 AG068635NIA NIH HHS R01 AG061875NIA NIH HHS R01 AG064165NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG068182NIA NIH HHS R01 AG071861NIA NIH HHS R01 AG076515NIA NIH HHS R01 AG082708NIA NIH HHS R33 AG061456NIA NIH HHS RF1 AG070391NIA NIH HHS U54 AG079754NIDDK NIH HHS R01 DK128552Wellcome Trust
Abstract
Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)
Indexed as
ApoptosisCellular SenescenceCytosolDNA, MitochondrialMitochondriaAnimalsbcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHealthy AgingInflammationLongevityMiceMitochondrial Transmembrane Permeability-Driven NecrosisPhenotypeProof of Concept StudyBak1 protein, mouseBax protein, mousebcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteincGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialSting1 protein, mouseSTING Protein
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.