Evidence map›Paper›PMID 37821701›Full record

ArticleNature2023

Structures illustrate step-by-step mitochondrial transcription initiation.

Quinten Goovaerts, Jiayu Shen, Brent De Wijngaert, Urmimala Basu, Smita S Patel, Kalyan Das

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. The molecular basis of transcription initiation by RNA polymerase II.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. The initiation of mitochondrial DNA replication.Biochemical Society transactions · 2024
    Review
  11. Article
  12. Review
  13. Understanding the impact ofFrontiers in molecular biosciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Quinten Goovaerts *Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID 0000-0002-2168-1103
Jiayu Shen *Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0001-8447-9378
Brent De WijngaertLaboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID 0000-0002-7551-8897
Urmimala BasuDepartment of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0003-4035-1246
Smita S PatelDepartment of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA. patelss@rwjms.rutgers.edu.ORCID 0000-0002-2523-4933
Kalyan DasLaboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium. kalyan.das@kuleuven.be.ORCID 0000-0002-8897-324X
Rega Institute for Medical Research · BERutgers, The State University of New Jersey · US

Funding

Mechanistic studies of nucleic acid enzymes involved in DNA replication, transcription, and innate immunity.R35GM118086 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SMITA S PATEL · 2016 to 2026
$8.9M
NIGMS NIH HHS R35 GM118086
6 · The paper itself

Abstract

Transcription initiation is a key regulatory step in gene expression during which RNA polymerase (RNAP) initiates RNA synthesis de novo, and the synthesized RNA at a specific length triggers the transition to the elongation phase. Mitochondria recruit a single-subunit RNAP and one or two auxiliary factors to initiate transcription. Previous studies have revealed the molecular architectures of yeast

Indexed as

MitochondriaSaccharomyces cerevisiaeTranscription Initiation, GeneticCryoelectron MicroscopyDNADNA-Directed RNA PolymerasesMitochondrial ProteinsNucleotidesRNASaccharomyces cerevisiae ProteinsTranscription FactorsDNADNA-Directed RNA PolymerasesMitochondrial ProteinsMTF1 protein, S cerevisiaeNucleotidesRNASaccharomyces cerevisiae ProteinsTranscription Factors

Identifiers

PMID37821701
PMCPMC10600007
OpenAlexW4387540909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.