ArticleNature2023
Design and testing of a humanized porcine donor for xenotransplantation.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 2 pooled it
76.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
168 citing papers in PubMed, 2 syntheses or guidelines pooled it, 240 citations in OpenAlex.
- Artificial Liver Support Systems in Acute Liver Failure and Acute-on-Chronic Liver Failure: Systematic Review and Meta-Analysis.Critical care explorations · 2025Pooled it
- Systematic Review and Comparative Outcomes Analysis of NHP Liver Allotransplants and Xenotransplants.XenotransplantationPooled it
- First-in-Human, Phase 1, Randomized, Double-Blind, Placebo-Controlled Study of TNX-1500, an Fc-Modified anti-CD154 Monoclonal Antibody, Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending Doses in Healthy Adults.Journal of clinical immunology · 2026Trial
- Review
- The global patent landscape of CRISPR-Cas applications in medicine.Nature biotechnology · 2026Article
- Education and Ethical Guidance for Organ Donation at the End-of-Life: An Ethical Guidance Statement from the Neurocritical Care Society.Neurocritical care · 2026Review
- Activating a patient-relevant pathogenic variant of a genetically defined heart disease in a humanized pig model.Lab animal · 2026Article
- Artificial intelligence in preclinical nonhuman primate xenotransplantation: bridging the gap from data complexity to clinical precision.Clinical transplantation and research · 2026Review
- Beyond immune rejection: integrative genetic engineering strategies for overcoming coagulopathy in xenotransplantation.Clinical transplantation and research · 2026Review
- Genetically Modified and Gene-Edited Organisms-Objectives, Public Perception and Applications.Biology · 2026Review
- Article
- Pig Matrix: a matched multiomics 3D regulatory genomics database for evolutionary and comparative analyses in pigs.Molecular biology and evolution · 2026Article
- The Potential of Composite Pig Islets-Kidney Xenotransplantation to Cure Diabetes and Renal Failure: A Suggested Modified Approach.Diabetes · 2026Review
- Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents.Nature medicine · 2026Article
- Low-vacuum scanning electron microscopy for informative three-dimensional imaging of cell/tissue architectures and biomedical target localization.Microscopy (Oxford, England) · 2026Review
- The influence of structural variants from 2445 pigs on gene expression and complex traits.Nature communications · 2026Article
- Future of xenotransplantation in Korea.Clinical transplantation and research · 2026Review
- Multiple human transgenes prolong survival of triple-carbohydrate knockout porcine kidney xenografts in nonhuman primates.Nature communications · 2026Article
- Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.Molecular therapy. Advances · 2026Article
- Breaking the immune barrier: construction of cartilaginous organoids using alpha-1,3-galactosyltransferase-deficient pig cartilage-derived particles.Journal of translational medicine · 2026Article
108 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
60 authors at 5 institutions in 1 country.
Ranjith P Anand *eGenesis, Cambridge, MA, USA.
Jacob V Layer *eGenesis, Cambridge, MA, USA.
David Heja *eGenesis, Cambridge, MA, USA.
Takayuki Hirose *Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7950-0961
Grace Lassiter *Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3891-8581
Daniel J Firl *eGenesis, Cambridge, MA, USA.ORCID 0000-0001-7993-6167
Violette B ParagaseGenesis, Cambridge, MA, USA.
Adam AkkadeGenesis, Cambridge, MA, USA.
Sagar ChhangawalaeGenesis, Cambridge, MA, USA.ORCID 0000-0001-9626-1034
Robert B ColvinDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4493-4150
Russell J ErnsteGenesis, Cambridge, MA, USA.
Nicholas EscheGenesis, Cambridge, MA, USA.
Kristen GetchelleGenesis, Cambridge, MA, USA.
Alexandra K GriffineGenesis, Cambridge, MA, USA.
Xiaoyun GuoeGenesis, Cambridge, MA, USA.
Katherine C HalleGenesis, Cambridge, MA, USA.ORCID 0000-0003-1091-6074
Paula HamiltoneGenesis, Cambridge, MA, USA.
Lokesh A KalekareGenesis, Cambridge, MA, USA.ORCID 0000-0001-8368-1291
Yinan KaneGenesis, Cambridge, MA, USA.
Ahmad KaradagiCenter for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1360-938X
Feng LieGenesis, Cambridge, MA, USA.ORCID 0000-0001-8528-4249
Susan C LoweGenesis, Cambridge, MA, USA.
Rudy MathesonCenter for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5004-8959
Claudia NehringeGenesis, Cambridge, MA, USA.
Ryo OtsukaCenter for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Matthew PandelakiseGenesis, Cambridge, MA, USA.
Robert A PolicastroeGenesis, Cambridge, MA, USA.
Rebecca PolseGenesis, Cambridge, MA, USA.
Luis QueirozeGenesis, Cambridge, MA, USA.
Ivy A RosalesDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0621-3202
William T SerkineGenesis, Cambridge, MA, USA.ORCID 0000-0001-8551-5035
Kathryn StiedeeGenesis, Cambridge, MA, USA.ORCID 0000-0002-0605-0581
Toshihide TomosugiCenter for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8715-9134
Yongqiang XueeGenesis, Cambridge, MA, USA.
Gabriel E ZentnereGenesis, Cambridge, MA, USA.ORCID 0000-0002-0801-7646
David Angeles-AlboreseGenesis, Cambridge, MA, USA.
J Chris ChaoeGenesis, Cambridge, MA, USA.
Juliet N CrabtreeeGenesis, Cambridge, MA, USA.
Sierra HarkeneGenesis, Cambridge, MA, USA.
Nicole HinkleeGenesis, Cambridge, MA, USA.
Tania LemoseGenesis, Cambridge, MA, USA.
Mailin LieGenesis, Cambridge, MA, USA.
Lorena PantanoeGenesis, Cambridge, MA, USA.
Denise StevenseGenesis, Cambridge, MA, USA.
Omar D SubedareGenesis, Cambridge, MA, USA.
Xiaoqing TaneGenesis, Cambridge, MA, USA.
Shiyi YineGenesis, Cambridge, MA, USA.
Imran J AnwarDuke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-5075-4148
David AufhauserDepartment of Surgery, Division of Transplantation, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID 0000-0001-9028-6046
Saverio CapuanoWisconsin National Primate Research Center, Madison, WI, USA.
Dixon B KaufmanDepartment of Surgery, Division of Transplantation, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID 0000-0003-3615-0994
Stuart J KnechtleDuke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Jean KwunDuke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-8563-5472
Dhanansayan ShanmuganayagamDepartment of Animal and Dairy Science, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-8882-1668
James F MarkmannCenter for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2762-6535
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3535-2076
Mike CurtiseGenesis, Cambridge, MA, USA.
Tatsuo KawaiCenter for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6900-4603
Michele E YoudeGenesis, Cambridge, MA, USA. michele.youd@egenesisbio.com.ORCID 0009-0001-4677-9115
Wenning QineGenesis, Cambridge, MA, USA. wenning.qin@egenesisbio.com.ORCID 0000-0001-9168-5102
Genesis Foundation · USHarvard University · USDuke Medical Center · USUniversity of Wisconsin–Madison · USElectrical Geodesics (United States) · US
Funding
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MTRAINING IN TRANSPLANTATION BIOLOGYT32AI007529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1998 to 2024
$6.4MNIAID NIH HHS T32 AI007529NIH HHS P51 OD011106
Abstract
Recent human decedent model studies
Indexed as
Graft RejectionKidney TransplantationMacaca fascicularisSwineTransplantation, HeterologousAnimalsAnimals, Genetically ModifiedEndothelial CellsHumansPolysaccharidesTransgenesPolysaccharides
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.