Evidence map›Paper›PMID 37821581›Full record

ArticleLeukemia2023

High-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disorders.

Sebastian Köhrer, Tobias Dittrich, Martin Schorb, Niels Weinhold, Isabella Haberbosch, Mandy Börmel, Gabor Pajor, Hartmut Goldschmidt, Carsten Müller-Tidow, Marc S Raab and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Sebastian Köhrer *Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4046-8586
Tobias Dittrich *Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6442-8255
Martin SchorbElectron Microscopy Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4910-1868
Niels WeinholdDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5464-3234
Isabella HaberboschClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Mandy BörmelElectron Microscopy Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4354-891X
Gabor PajorClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Hartmut GoldschmidtDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Carsten Müller-TidowDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Marc S RaabClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Lukas JohnClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8178-6890
Anja SeckingerDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Alexander BrobeilInstitute of Pathology, University of Heidelberg, Heidelberg, Germany.
Peter DregerDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7429-8570
Tamás TornóczkyDepartment of Pathology, University of Pécs Medical School and Clinic, Pécs, Hungary.
László PajorDepartment of Pathology, University of Pécs Medical School and Clinic, Pécs, Hungary.
Ute HegenbartDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1917-6746
Stefan O SchönlandDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4853-5579
Yannick SchwabCell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. yannick.schwab@embl.de.
Alwin KrämerClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. a.kraemer@dkfz.de.ORCID http://orcid.org/0000-0001-8232-9982
Heidelberg University · DEGerman Cancer Research Center · DEEuropean Molecular Biology Laboratory · DEUniversity of Pecs · HUEuropean Bioinformatics Institute · GB

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) HE 8472/1-1Deutsche Forschungsgemeinschaft (German Research Foundation) KR 1981/4-1Deutsche Forschungsgemeinschaft (German Research Foundation) SCHO 1364/2-1
6 · The paper itself

Abstract

Plasma cell disorders are clonal outgrowths of pre-malignant or malignant plasma cells, characterized by extensive chromosomal aberrations. Centrosome abnormalities are a major driver of chromosomal instability in cancer but their origin, incidence, and composition in primary tumor cells is poorly understood. Using cutting-edge, semi-automated high-throughput electron tomography, we characterized at nanoscale 1386 centrioles in CD138

Indexed as

CentriolesPlasma CellsCell CycleCentrosomeElectron Microscope TomographyHumans

Identifiers

PMID37821581
PMCPMC10681902
OpenAlexW4387532154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.