Evidence map›Paper›PMID 37821426›Full record

ArticleNature communications2023

A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus.

Qiang Liu, Benjamin J Bell, Dong Won Kim, Sang Soo Lee, Mehmet F Keles, Qili Liu, Ian D Blum, Annette A Wang, Elijah J Blank, Jiali Xiong and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. mWAKE in the Central Amygdala Regulates Fear Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. [Activation of astrocytes in the dorsomedial hypothalamus accelerates sevoflurane anesthesia emergence in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  9. Review
  10. Article
  11. Tob Regulates the Timing of Sleep Onset at Night inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Qiang Liu *Department of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Benjamin J Bell *Department of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Dong Won KimSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0001-8624-0168
Sang Soo LeeDepartment of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Mehmet F KelesDepartment of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0001-6673-1613
Qili LiuDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, 94158, USA.
Ian D BlumDepartment of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0001-6999-8364
Annette A WangDepartment of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Elijah J BlankBiochemistry, Cellular and Molecular Biology Program, Johns Hopkins University, Baltimore, MD, 21205, USA.
Jiali XiongBiochemistry, Cellular and Molecular Biology Program, Johns Hopkins University, Baltimore, MD, 21205, USA.
Joseph L BedontSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, 21205, USA.
Anna J ChangSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, 21205, USA.
Habon IssaDepartment of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Jeremiah Y CohenAllen Institute for Neural Dynamics, Seattle, WA, 98109, USA.ORCID 0000-0002-4768-7124
Seth BlackshawSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0002-1338-8476
Mark N WuDepartment of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA. marknwu@jhmi.edu.ORCID 0000-0002-1329-0655
Johns Hopkins University · USAllen Institute · US

Funding

Cross-Species Analyses of the Molecular and Circuit Basis ofSleepR35NS122181 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Mark N Wu · 2021 to 2026
$6.9M
Genetic Analysis of Sleep RegulationR01NS079584 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WU, MARK N · 2012 to 2020
$3.2M
Molecular and Cellular Mechanisms Underlying the Circadian Timing of SleepR01NS094571 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WU, MARK N · 2016 to 2020
$2.5M
Development and function of hypothalamic Lhx6-positive neuronsR01MH126676 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2021 to 2025
$2.0M
LSM880 Laser-scanning Microscope with Airyscan ModuleS10OD023548 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2018 to 2018
$439k
NIH HHS S10 OD023548NIMH NIH HHS R01 MH126676NINDS NIH HHS R01 NS079584NINDS NIH HHS R01 NS094571NINDS NIH HHS R35 NS122181
6 · The paper itself

Abstract

Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular mechanisms remain unclear. In Drosophila, the clock output molecule WIDE AWAKE (WAKE) labels rhythmic neural networks and cyclically regulates sleep and arousal. Here, we show, in a male mouse model, that mWAKE/ANKFN1 labels a subpopulation of dorsomedial hypothalamus (DMH) neurons involved in rhythmic arousal and acts in the DMH to reduce arousal at night. In vivo Ca

Indexed as

Circadian ClocksSleepAnimalsArousalCircadian RhythmHypothalamusMaleMiceNeurons

Identifiers

PMID37821426
PMCPMC10567910
OpenAlexW4387526310

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.