Evidence map›Paper›PMID 37821381›Full record

ArticleThe Journal of veterinary medical science2023

Senile plaques and phosphorylated tau deposition in a super-aged rhesus monkey (Macaca mulatta).

Susumu Iwaide, Yutaro Nakayama, James K Chambers, Kazuyuki Uchida, Daisuke Nakagawa, Yumi Yamanashi, Haruna Bando, Tomoaki Murakami

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Susumu IwaideLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Yutaro NakayamaLaboratory of Veterinary Pathology, The University of Tokyo, Tokyo, Japan.
James K ChambersLaboratory of Veterinary Pathology, The University of Tokyo, Tokyo, Japan.
Kazuyuki UchidaLaboratory of Veterinary Pathology, The University of Tokyo, Tokyo, Japan.
Daisuke NakagawaKyoto City Zoo, Kyoto, Japan.
Yumi YamanashiKyoto City Zoo, Kyoto, Japan.
Haruna BandoKyoto City Zoo, Kyoto, Japan.
Tomoaki MurakamiLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Kyoto City Zoo · JPTokyo University of Agriculture and Technology · JPUniversity of Tokyo Hospital · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain of a rhesus monkey that died at 43 years of age with symptoms of suspected cognitive dysfunction was analyzed. pathological analyses revealed characteristic Alzheimer's disease-related lesions: the aggregation of amyloid β (Aβ) in the form of senile plaques and phosphorylated tau proteins. We also revealed that Aβ43, which is prone to aggregation and toxicity in humans, is involved in senile plaques in the brain of the rhesus monkey, as well as several other Aβ species. Comparative studies of neuropathology using aged nonhuman primates lack behavioral descriptions compared to human medicine. This case report showed behavioral abnormalities and the detailed pathological changes that may have caused it in a super-aged rhesus monkey.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainMacaca mulattaPlaque, Amyloidtau ProteinsAmyloid beta-Peptidestau ProteinsAlzheimer’s diseaseamyloid βneurofibrillary tanglesrhesus monkeytau

Identifiers

PMID37821381
PMCPMC10788178
OpenAlexW4387546864

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.